Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein

被引：145

作者：

Slupska, MM

Luther, WM

Chiang, JH

Yang, HJ

Miller, JH ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Microbiol & Mol Genet, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA

来源：

JOURNAL OF BACTERIOLOGY | 1999年 / 181卷 / 19期

关键词：

D O I：

10.1128/JB.181.19.6210-6213.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

We have previously described the hMYH cDNA and genomic clones (M. M. Slupska ct al., J. Bacteriol. 178:3885-3892, 1996). Here, vue report that the enzyme expressed from an hMYH cDNA clone in Escherichia coli complements the mutator phenotype in a mutY mutant and can remove A from an A 8-hydroxydeoxyguanine mismatch and to a lesser extent can remove A from an A.G mismatch in vitro.

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页码：6210 / 6213

页数：4

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