Multifunctional nanomicellar systems for delivering anticancer drugs

被引：33

作者：

Chen, Yi-Chun ^{[1
,2
,3
]}

Lo, Chun-Liang ^{[4
]}

Hsiue, Ging-Ho ^{[1
,2
,3
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 300, Taiwan

[2] Chung Yuan Christian Univ, Dept Chem Engn, Chungli 320, Taiwan

[3] Chung Yuan Christian Univ, R&D Ctr Membrane Technol, Chungli 320, Taiwan

[4] Natl Yang Ming Univ, Dept Biomed Engn, Taipei 112, Taiwan

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2014年 / 102卷 / 06期

关键词：

micelles; stimuli responsive; controlled drug delivery; cancer therapy; tumor targeting; BIODEGRADABLE POLYMERIC MICELLES; BLOCK-COPOLYMER MICELLES; IN-VIVO EVALUATION; DIBLOCK COPOLYMERS; CANCER-THERAPY; N-ISOPROPYLACRYLAMIDE; PHOTODYNAMIC THERAPY; MULTIDRUG-RESISTANCE; PIRARUBICIN MICELLES; RESPONSIVE MICELLES;

D O I：

10.1002/jbm.a.34850

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Most anticancer drugs cause severe side effect due to the lack of selectivity for cancer cells. In recent years, new strategies of micellar systems, which design for specifically target anticancer drugs to tumors, are developed at the forefront of polymeric science. To improve efficiency of delivery and cancer specificity, considerable emphasis has been placed on the development of micellar systems with passive and active targeting. In this review article, we summarized various strategies of designing multifunctional micellar systems in the purpose of improving delivery efficiency. Micellar systems compose of a multifunctional copolymer or a mixture of two or more copolymers with different properties is a plausible approach to tuning the resulting properties and satisfied various requirements for anticancer drug delivery. It appears that multifunctional micellar systems hold great potential in cancer therapy. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2024-2038, 2014.

引用

页码：2024 / 2038

页数：15

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