Dendrimer-silver complexes and nanocomposites as antimicrobial agents

被引:333
作者
Balogh, L [1 ]
Swanson, DR [1 ]
Tomalia, DA [1 ]
Hagnauer, GL [1 ]
McManus, AT [1 ]
机构
[1] Univ Michigan, Dept Internal Med, Ctr Biol Nanotechnol, Ann Arbor, MI 48109 USA
关键词
D O I
10.1021/nl005502p
中图分类号
O6 [化学];
学科分类号
0703 [化学];
摘要
Silver complexes of poly(amidoamine) (PAMAM) dendrimers as well as different {silver-PAMAM} dendrimer nanocomposite solutions have been tested in vitro against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli bacteria, using the standard agar overlay method. Both PAMAM silver salts and nanocomposites displayed considerable antimicrobial activity without the loss of solubility and activity, even in the presence of sulfate or chloride ions.
引用
收藏
页码:18 / 21
页数:4
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