Synthesis of (S)-1-(4-hydroxyphenyl)alcohols by eugenol dehydrogenase from Pseudomonas fluorescens E118

被引：9

作者：

Wieser, M

Furukawa, H

Morita, H

Yoshida, T

Nagasawa, T ^{[1
]}

机构：

[1] Gifu Univ, Fac Engn, Dept Biomol Sci, Gifu 5011193, Japan

[2] Chisso Corp, Yokohama Res Ctr, Kanazawa Ku, Yokohama, Kanagawa 2368605, Japan

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 09期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0957-4166(99)00164-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(S)-1-(4-Hydroxyphenyl)ethanol and (S)-1-(4-hydroxyphenyl)propanol were synthesized with enantiomeric excesses of 96.6% and 95.2%, respectively, from the corresponding 4-alkylphenols by eugenol dehydrogenase from Pseudomonas fluorescens E118. The enantioselectivity of the enzyme was shown to be pH-dependent. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1627 / 1630

页数：4

共 9 条

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[2]

BATT DG, 1991, Patent No. 11445

[3]

COREY EJ, 1976, TETRAHEDRON LETT, V11, P809

[4] A FACILE GENERAL-ROUTE TO ENANTIOMERIC 1-(4-HYDROXYPHENYL)ALKANOLS, AND AN IMPROVED SYNTHESIS OF 4-VINYLPHENOL [J].