Concomitant and conformational polymorphism, conformational isomorphism, and phase relationships in 4-cyanopyridine•4,4′-biphenol cocrystals

被引：51

作者：

Bis, JA ^{[1
]}

Vishweshwar, P ^{[1
]}

Middleton, RA ^{[1
]}

Zaworotko, MJ ^{[1
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

来源：

CRYSTAL GROWTH & DESIGN | 2006年 / 6卷 / 04期

关键词：

D O I：

10.1021/cg0680024

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The 2:1 co-crystal of 4-cyanopyridine and 4,4'-biphenol exists in at least two polymorphic forms. Single-crystal X-ray crystallographic analysis of forms I and II revealed conformational differences in the 4,4'-biphenol molecules, but O-H center dot center dot center dot N(pyridine) supramolecular heterosynthons sustain both forms, suggesting that O-H center dot center dot center dot N(pyridine) interactions are favored over competing O-H center dot center dot center dot N(cyano) interactions. These conformational polymorphs crystallize concomitantly, and conformational isomorphism is also observed in this co-crystal. Experimental conditions that induce transformations between form I and form II are described. The structural differences between form I and II are discussed in the broader context of conformational polymorphism.

引用

页码：1048 / 1053

页数：6

共 69 条

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