Inhibitors of Lysine Biosynthesis as Antibacterial Agents

被引：92

作者：

Hutton, Craig A. ^{[1
]}

Southwood, Timothy J. ^{[1
]}

Turner, Jennifer J. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 02期

关键词：

Lysine; DAP pathway; diaminopimelate; antibiotics; enzyme inhibitors;

D O I：

10.2174/1389557033405359

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides both lysine for protein synthesis and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. Recent studies of the enzymes of the lysine biosynthetic pathway, development of inhibitors and investigations of their antibacterial properties are discussed.

引用

页码：115 / 127

页数：13

共 88 条

[1] SYNTHESIS AND TESTING OF HETEROCYCLIC-ANALOGS OF DIAMINOPIMELIC ACID (DAP) AS INHIBITORS OF DAP DEHYDROGENASE AND DAP EPIMERASE
ABBOTT, SD
LANEBELL, P
SIDHU, KPS
VEDERAS, JC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (15) : 6513 - 6520
[2] PURIFICATION AND PROPERTIES OF MESO-ALPHA,EPSILON-DIAMINOPIMELATE DECARBOXYLASE FROM BACILLUS-SPHAERICUS
ASADA, Y
TANIZAWA, K
KAWABATA, Y
MISONO, H
SODA, K
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1981, 45 (06): : 1513 - 1514
[3] STEREOCHEMISTRY OF MESO-ALPHA,EPSILON-DIAMINOPIMELATE DECARBOXYLASE REACTION - THE 1ST EVIDENCE FOR PYRIDOXAL 5'-PHOSPHATE DEPENDENT DECARBOXYLATION WITH INVERSION OF CONFIGURATION
ASADA, Y
TANIZAWA, K
SAWADA, S
SUZUKI, T
MISONO, H
SODA, K
[J]. BIOCHEMISTRY, 1981, 20 (24) : 6881 - 6886
[4] Acyl group specificity at the active site of tetrahydrodipicolinate N-succinyltransferase
Beaman, TW
Vogel, KW
Drueckhammer, DG
Blanchard, JS
Roderick, SL
[J]. PROTEIN SCIENCE, 2002, 11 (04) : 974 - 979
[5] The conformational change and active site structure of tetrahydrodipicolinate N-succinyltransferase
Beaman, TW
Blanchard, JS
Roderick, SL
[J]. BIOCHEMISTRY, 1998, 37 (29) : 10363 - 10369
[6] ENERGETICS OF PROLINE RACEMASE - DOUBLE FRACTIONATION EXPERIMENT, A TEST FOR CONCERTEDNESS AND FOR TRANSITION-STATE DOMINANCE
BELASCO, JG
ALBERY, WJ
KNOWLES, JR
[J]. BIOCHEMISTRY, 1986, 25 (09) : 2552 - 2558
[7] BERGES DA, 1986, J BIOL CHEM, V261, P6160
[8] Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy
Blickling, S
Renner, C
Laber, B
Pohlenz, HD
Holak, TA
Huber, R
[J]. BIOCHEMISTRY, 1997, 36 (01) : 24 - 33
[9] Structure of dihydrodipicolinate synthase of Nicotiana sylvestris reveals novel quaternary structure
Blickling, S
Beisel, HG
Bozic, D
Knäblein, J
Laber, B
Huber, R
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1997, 274 (04) : 608 - 621
[10] STEREOSELECTIVE SYNTHESIS OF (2S,6S)-2,6-DIAMINOHEPTANEDIOIC ACID AND OF UNSYMMETRICAL DERIVATIVES OF MESO-2,6-DIAMINOHEPTANEDIOIC ACID
BOLD, G
ALLMENDINGER, T
HEROLD, P
MOESCH, L
SCHAR, HP
DUTHALER, RO
[J]. HELVETICA CHIMICA ACTA, 1992, 75 (03) : 865 - 882

← 1 2 3 4 5 6 7 8 9 →