17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception

被引：133

作者：

Bang, S. ^{[1
]}

Yoo, S. ^{[1
]}

Yang, T. J. ^{[1
]}

Cho, H. ^{[2
]}

Hwang, S. W. ^{[1
]}

机构：

[1] Korea Univ, Grad Sch Med, Seoul, South Korea

[2] Seoul Natl Univ, Sensory Res Ctr, CRI, Coll Pharm, Seoul, South Korea

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2012年 / 165卷 / 03期

关键词：

17(R)-resolvin D1; TRPV3; specific inhibitor; pain; keratinocytes; nociceptive behaviours; inflammation; RESOLVIN D1; CAPSAICIN RECEPTOR; INFLAMMATORY HYPERALGESIA; MECHANICAL HYPERALGESIA; NOCICEPTIVE NEURONS; SENSORY NEURONS; PAIN; ACTIVATION; TRPV3; BRADYKININ;

D O I：

10.1111/j.1476-5381.2011.01568.x

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

BACKGROUND AND PURPOSE Transient receptor potential ion channel vanilloid 3 (TRPV3) is expressed in skin keratinocytes and plays an important role in thermal and chemical nociceptions in the periphery. The presence of TRPV3 inhibitors would improve our understanding of TRPV3 function and help to develop receptor-specific analgesics. However, little is known about physiological substances that specifically inhibit TRPV3 activity. Here, we investigated whether 17(R)-resolvin D1 (17R-RvD1), a naturally occurring pro-resolving lipid specifically affects TRPV3 activity.

引用

页码：683 / 692

页数：10

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