High Levels of Serum Uric Acid Predict Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome

被引：112

作者：

Duran, Mustafa ^{[1
]}

Kalay, Nihat ^{[2
]}

Akpek, Mahmut ^{[2
]}

Orscelik, Ozcan ^{[2
]}

Elcik, Deniz ^{[2
]}

Ocak, Ayse ^{[3
]}

Inanc, Mehmet Tugrul ^{[2
]}

Kasapkara, H. Ahmet ^{[4
]}

Oguzhan, Abdurrahman ^{[2
]}

Eryol, Namik K. ^{[2
]}

Ergin, Ali ^{[2
]}

Kaya, Mehmet Gungor ^{[2
]}

机构：

[1] Kayseri Res & Educ Hosp, Dept Cardiol, Kayseri, Turkey

[2] Erciyes Univ, Dept Cardiol, Kayseri, Turkey

[3] Erciyes Univ, Dept Internal Med, Kayseri, Turkey

[4] Ataturk Training & Res Hosp, Ankara, Turkey

来源：

ANGIOLOGY | 2012年 / 63卷 / 06期

关键词：

serum uric acid; Gensini score; acute coronary syndrome; HEART-DISEASE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; INDEPENDENT PREDICTOR; RENAL-FUNCTION; ALL-CAUSE; RISK; HYPERURICEMIA; ASSOCIATION; MORTALITY;

D O I：

10.1177/0003319711426868

中图分类号：

R6 [外科学];

学科分类号：

100210 [外科学];

摘要：

We aimed to elucidate the relation between serum uric acid (SUA) level and severity of coronary artery disease (CAD) in nondiabetic, nonhypertensive patients (n = 246) with acute coronary syndrome (ACS). Severity of CAD was assessed by the Gensini score. One, 2, and 3 or more diseased vessels were identified in 87 (35.4%), 55 (22.4%), and 104 (42.2%) patients, respectively. Patients with hyperuricemia had higher Gensini score, high number of diseased vessels, critical lesions, and total occlusion. Serum uric acid level was significantly associated with number of diseased vessels. Serum uric acid was an independent risk factor for multivessel disease by univariate analysis. High levels of SUA associated with the severity of CAD in nondiabetic, nonhypertensive patients with ACS.

引用

页码：448 / 452

页数：5

共 35 条

[1]

Relation between serum uric acid and lower limb blood flow in patients with chronic heart failure [J].

Anker, SD ;

Leyva, F ;

PooleWilson, PA ;

Kox, WJ ;

Stevenson, JC ;

Coats, AJS .

HEART, 1997, 78 (01) :39-43

[2]

Effect of statin treatment on renal function and serum uric acid levels and their relation to vascular events in patients with coronary heart disease and metabolic syndrome - A subgroup analysis of the GREek Atorvastatin and Coronary heart disease Evaluation (GREACE) Study [J].

Athyros, Vasilios G. ;

Mikhailidis, Dimitri P. ;

Liberopoulos, Evangelos N. ;

Kakafika, Anna I. ;

Karagiannis, Asterios ;

Papageorgiou, Athanasios A. ;

Tziomalos, Konstantinos ;

Ganotakis, Emmanuel S. ;

Elisaf, Moses .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2007, 22 (01) :118-127

[3]

Association between the changes in renal function and serum uric acid levels during multifactorial intervention and clinical outcome in patients with metabolic syndrome. A post hoc analysis of the ATTEMPT study [J].

Athyros, Vassilios G. ;

Karagiannis, Asterios ;

Ganotakis, Emmanouel S. ;

Paletas, Konstantinos ;

Nicolaou, Vassilios ;

Bacharoudis, George ;

Tziomalos, Konstantinos ;

Alexandrides, Theodore ;

Liberopoulos, Evangelos N. ;

Mikhailidis, Dimitri P. .

CURRENT MEDICAL RESEARCH AND OPINION, 2011, 27 (08) :1659-1668

[4]

Serum Uric Acid Level as an Independent Risk Factor for All-Cause, Cardiovascular, and Ischemic Stroke Mortality: A Chinese Cohort Study [J].

Chen, Jiunn-Horng ;

Chuang, Shao-Yuan ;

Chen, Hsin-Jen ;

Yeh, Wen-Ting ;

Pan, Wen-Harn .

ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2009, 61 (02) :225-232

[5]

Effect on serum uric acid levels of drugs prescribed for indications other than treating hyperuricaemia [J].

Daskalopoulou, SS ;

Tzovaras, V ;

Mikhailidis, DP ;

Elisaf, M .

CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (32) :4161-4175

[6]

Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease? [J].

Dawson, Jesse ;

Walters, Matthew .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 62 (06) :633-644

[7]

The association between serum uric acid level and coronary artery disease [J].

Deveci, O. Sinan ;

Kabakci, G. ;

Okutucu, S. ;

Tulumen, E. ;

Aksoy, H. ;

Kaya, E. Baris ;

Evranos, B. ;

Aytemir, K. ;

Tokgozoglu, L. ;

Oto, A. .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2010, 64 (07) :900-907

[8]

Uric acid and cardiovascular risk [J].

Feig, Daniel I. ;

Kang, Duk-Hee ;

Johnson, Richard J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (17) :1811-1821

[9]

Uric acid: A marker of increased cardiovascular risk [J].

Gagliardi, Ana C. M. ;

Miname, Marcio H. ;

Santos, Raul D. .

ATHEROSCLEROSIS, 2009, 202 (01) :11-17

[10]

A MORE MEANINGFUL SCORING SYSTEM FOR DETERMINING THE SEVERITY OF CORONARY HEART-DISEASE [J].

GENSINI, GG .

AMERICAN JOURNAL OF CARDIOLOGY, 1983, 51 (03) :606-606

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