Molecular Evidence of Cryptotanshinone for Treatment and Prevention of Human Cancer

被引：122

作者：

Chen, Wenxing ^{[1
,2
]}

Lu, Yin ^{[1
,2
]}

Chen, Guangying ^{[3
]}

Huang, Shile ^{[4
,5
]}

机构：

[1] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210046, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Jiangsu Key Lab Pharmacol & Safety Evaluat Chines, Nanjing 210046, Jiangsu, Peoples R China

[3] Hainan Normal Univ, Coll Chem & Chem Engn, Haikou 571158, Peoples R China

[4] Louisiana State Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Shreveport, LA 71105 USA

[5] Louisiana State Univ, Hlth Sci Ctr, Feist Weiller Canc Ctr, Shreveport, LA 71105 USA

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2013年 / 13卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Cryptotanshinone; tanshinones; cancer; cell proliferation; cell death; mTOR; SALVIA-MILTIORRHIZA INHIBIT; CELL TUBE FORMATION; NF-KAPPA-B; PROSTATE-CANCER; SIGNALING PATHWAY; TANSHINONE-IIA; DITERPENOID TANSHINONES; MESSENGER-RNA; IN-VITRO; APOPTOSIS;

D O I：

10.2174/18715206113139990115

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cryptotanshinone is one of the major tanshinones isolated from the roots of the plant Salvia miltiorrhiza Bunge (Danshen). Danshen has been widely used in traditional Chinese medicine for treatment of a variety of diseases, including coronary artery disease, acute ischemic stroke, hyperlipidemia, chronic renal failure, chronic hepatitis, and Alzheimer's disease, showing no serious adverse effects. Recent studies have shown that cryptotanshinone not only possesses the potential for treatment and prevention of the above-mentioned diseases, but also is a potent anticancer agent. Here we briefly summarize the physical and chemical properties and the pharmacokinetic profiles of cryptotanshinone, and then comprehensively review its anticancer activities as well as the underlying mechanisms.

引用

页码：979 / 987

页数：9

共 89 条

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