Dynamic regulation of DNA methylation coupled transcriptional repression: BDNF regulation by MeCP2

被引：10

作者：

Wade, PA ^{[1
]}

机构：

[1] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

来源：

BIOESSAYS | 2004年 / 26卷 / 03期

关键词：

D O I：

10.1002/bies.20018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recurrent theme in eukaryotic genome regulation stipulates that the properties of DNA are strongly influenced by the nucleoprotein complex. into which it is assembled. Methylation of cytosine residues in vertebrate genomes has been implicated in influencing the assembly of locally repressive chromatin architecture. Current models suggest that covalent modification of DNA results in heritable, long-term transcriptional silencing. In October of 2003, two manuscripts (1,2) were published that challenge important aspects of this model, suggesting that modulation of both DNA methylation itself, as well as the machinery implicated in its interpretation, are involved in acute gene regulation. BioEssays 26:217-220, 2004. (C) 2004 Wiley Periodicals, Inc.

引用

页码：217 / 220

页数：4

共 24 条

[1] Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 [J].

Amir, RE ;

Van den Veyver, IB ;

Wan, M ;

Tran, CQ ;

Francke, U ;

Zoghbi, HY .

NATURE GENETICS, 1999, 23 (02) :185-188

[2] The DNA methyltransferases of mammals [J].

Bestor, TH .

HUMAN MOLECULAR GENETICS, 2000, 9 (16) :2395-2402

[3] Methylation-induced repression - Belts, braces, and chromatin [J].

Bird, AP ;

Wolffe, AP .

CELL, 1999, 99 (05) :451-454

[4] Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice [J].

Chen, RZ ;

Akbarian, S ;

Tudor, M ;

Jaenisch, R .

NATURE GENETICS, 2001, 27 (03) :327-331

[5] Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2 [J].

Chen, WG ;

Chang, Q ;

Lin, YX ;

Meissner, A ;

West, AE ;

Griffith, EC ;

Jaenisch, R ;

Greenberg, ME .

SCIENCE, 2003, 302 (5646) :885-889

[6]

Chen WG, 2003, J NEUROSCI, V23, P2572

[7] Maintenance of stable heterochromatin domains by dynamic HP1 binding [J].

Cheutin, T ;

McNairn, AJ ;

Jenuwein, T ;

Gilbert, DM ;

Singh, PB ;

Misteli, T .

SCIENCE, 2003, 299 (5607) :721-725

[8] Modulation of heterochromatin protein 1 dynamics in primary mammalian cells [J].

Festenstein, R ;

Pagakis, SN ;

Hiragami, K ;

Lyon, D ;

Verreault, A ;

Sekkali, B ;

Kioussis, D .

SCIENCE, 2003, 299 (5607) :719-721

[9] Chromatin compaction by human MeCP2 - Assembly of novel secondary chromatin structures in the absence of DNA methylation [J].

Georgel, PT ;

Horowitz-Scherer, RA ;

Adkins, N ;

Woodcock, CL ;

Wade, PA ;

Hansen, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (34) :32181-32188

[10] A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome [J].

Guy, J ;

Hendrich, B ;

Holmes, M ;

Martin, JE ;

Bird, A .

NATURE GENETICS, 2001, 27 (03) :322-326

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