Interleukin-1 beta sensitizes the response of the gastric vagal afferent to cholecystokinin in rat

被引：40

作者：

Bucinskaite, V

Kurosawa, M

Miyasaka, K

Funakoshi, A

Lundeberg, T

机构：

[1] INT UNIV HLTH & WELF,DEPT PHYSIOL,OHTAWARRA,JAPAN

[2] TOKYO METROPOLITAN INST GERONTOL,DEPT CLIN PATHOL,TOKYO,JAPAN

[3] KYUSHU NATL CANC CTR,FUKUOKA,JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 229卷 / 01期

关键词：

interleukin-1; cholecystokinin; type A cholecystokinin receptor; vagal afferent nerve; rat;

D O I：

10.1016/S0304-3940(97)00406-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interleukin-1 beta (IL-1 beta) and cholecystokinin (CCK) are important mediators in the development of anorexic response during disease. The role of IL-1 beta and CCK in the peripheral mechanisms of anorexia was studied by recording the mass afferent activity of the gastric vagal nerve in anesthetized rats. The i.v. administration of CCK (1 nmol) increased the activity of the vagal nerve, and this response was raised by 55-72% 2 h after i.v. injection of IL-1 beta. It is proposed that IL-1 beta-induced anorexia is mediated via the sensitization of type A CCK receptors in the periphery. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：33 / 36

页数：4

共 23 条

[1]

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[2]

BEUTLER BA, 1985, J IMMUNOL, V135, P3969

[3] EFFECTS OF CHOLECYSTOKININ (CCK-8) ON 2 CLASSES OF GASTRODUODENAL VAGAL AFFERENT FIBER [J].