Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors

被引：258

作者：

Figueira, Rita ^{[1
]}

Holden, David W. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Microbiol Sect, Ctr Mol Microbiol & Infect, London SW7 2AZ, England

来源：

MICROBIOLOGY-SGM | 2012年 / 158卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

ENTERICA SEROVAR TYPHIMURIUM; E3 UBIQUITIN LIGASES; LEUCINE-RICH REPEAT; LYSOSOMAL MEMBRANE-GLYCOPROTEINS; PHOSPHOTHREONINE LYASE ACTIVITY; PROTEIN-KINASE PKN1; NF-KAPPA-B; VIRULENCE PROTEIN; EPITHELIAL-CELLS; INTRACELLULAR SALMONELLA;

D O I：

10.1099/mic.0.058115-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Salmonella enterica serovars cause severe disease in humans, such as gastroenteritis and typhoid fever. The bacteria are able to invade and replicate within host cells, including epithelial cells and macrophages. Pathogenesis of Salmonella is facilitated by a type III secretion system (T3SS) encoded by genes of Salmonella pathogenicity island 2 (SPI-2). Intracellular replication occurs in a specialized membrane compartment, the Salmonella-containing vacuole (SCV), and depends on translocation of approximately 30 effector proteins via the SPI-2 T3SS into the host endomembrane system and cytoplasm. In this review we discuss the many different functions of these effectors, which range from maintaining the integrity of the SCV and its juxtanuclear location, to interference with the host cytoskeleton and immune signalling.

引用

页码：1147 / 1161

页数：15

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