Air-Stable and Phosphine-Free Iridium Catalysts for Highly Enantioselective Hydrogenation of Quinoline Derivatives

被引：134

作者：

Li, Zhi-Wei ^{[1
]}

Wang, Tian-Li ^{[1
]}

He, Yan-Mei ^{[1
]}

Wang, Zhi-Jian ^{[1
]}

Fan, Qing-Hua ^{[1
]}

Pan, Jie ^{[1
]}

Xu, Li-Jun ^{[2
]}

机构：

[1] Chinese Acad Sci, Ctr Chem Biol, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

[2] Renmin Univ China, Dept Chem, Beijing 100972, Peoples R China

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 22期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1021/ol802016w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective hydrogenation of quinoline derivatives catalyzed by phosphine-free chiral cationic Cp*Ir(OTf)(CF3TsDPEN) complex (CF3TsDPEN = N-(p-trifluoromethylbenzenesulfonyl)-1,2-diphenylethylene-diamine) afforded the 1,2,3,4-tetrahydroquinoline derivatives in up to 99% ee. The reaction could be carried out with a substrate-to-catalyst molar ratio as high as 1000 in undegassed methanol and with no need for inert gas protection.

引用

页码：5265 / 5268

页数：4

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