Fatal immune haemolysis due to a degradation product of ceftriaxone

被引：26

作者：

Meyer, O

Hackstein, H

Hoppe, B

Göbel, FJ

Bein, G

Salama, A

机构：

[1] Humboldt Univ, Fak Med, Blutbank, Charite, D-13353 Berlin, Germany

[2] Univ Giessen, Inst Transfus Med & Immunhamatol, D-35390 Giessen, Germany

[3] DRK Kinderklin Siegen, Siegen, Germany

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1999年 / 105卷 / 04期

关键词：

immune haemolytic anaemia; drug-dependent antibodies; cephalosporin; ceftriaxone;

D O I：

10.1046/j.1365-2141.1999.01434.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 16-year-old girl who was treated with ceftriaxone developed two intravascular haemolytic attacks that led to acute renal failure and death, The direct antiglobulin test was positive only for C3d, and no ceftriaxone-dependent antibodies were detectable. Her serum reacted strongly positive with red blood cells in the presence of ex vivo antigen related to ceftriaxone (urine samples from patients receiving the drug), This is the first reported case in which the causative antibodies appeared to be stimulated solely by a degradation product of ceftriaxone.

引用

页码：1084 / 1085

页数：2

共 11 条

[1]

[Anonymous], IMMUNE HEMOLYTIC ANE

[2] FATAL HEMOLYSIS INDUCED BY CEFTRIAXONE IN A CHILD WITH SICKLE-CELL-ANEMIA [J].