Hepatitis B virus transgenic mouse model of chronic liver disease

被引：56

作者：

Larkin, J

Clayton, M

Sun, B

Perchonock, CE

Morgan, JL

Siracusa, LD

Michaels, FH

Feitelson, MA

机构：

[1] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Microbiol & Immunol, Philadelphia, PA 19107 USA

来源：

NATURE MEDICINE | 1999年 / 5卷 / 08期

关键词：

D O I：

10.1038/11347

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A model for hepatitis B virus-associated chronic liver disease has been made using cloned hepatitis B virus DNA as a transgene in a severe combined immunodeficient host. These mice consistently support virus gene expression and replication. After adoptive transfer of unprimed, syngeneic splenocytes, these mice cleared virus from liver and serum, and developed chronic liver disease. This model will permit identification of the host and virus contributions to chronic liver disease in the absence of tolerance.

引用

收藏

页码：907 / 912

页数：6

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