Synthesis of the first water-soluble chiral tetrahydroxy diphosphine Rh(I) catalyst for enantioselective hydrogenation

被引：55

作者：

Holz, J

Heller, D

Stürmer, R

Börner, A

机构：

[1] Univ Rostock, Inst Organ Katalyseforsch, D-18055 Rostock, Germany

[2] BASF Aktiengesell, Hauptlab ZHFD, Feinchemikalien, D-67056 Ludwigshafen, Germany

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 39期

关键词：

asymmetric synthesis; hydrogenation; phosphines; rhodium; rhodium compounds;

D O I：

10.1016/S0040-4039(99)01458-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the first chiral polyhydroxy diphosphine-Rh(I) catalyst for asymmetric hydrogenation is described. Based on a simple synthetic pathway starting from D-mannitol the new metal complex is constructed. A special feature of the approach is the protection of the air-sensitive phosphine groups by the catalytically active metal in the final synthetic steps. Therefore, tedious P-protection-deprotection procedures could be advantageously avoided. The new water-soluble catalyst hydrogenates functionalized olefins by up to 99.6% ee in water as solvent. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7059 / 7062

页数：4

共 33 条

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