CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment

被引：49

作者：

Liu, YZ

Thomas, NSB

Latchman, DS

机构：

[1] UCL, Windeyer Inst Med Sci, Dept Mol Pathol, London W1P 6DB, England

[2] UCL, Royal Free & Univ Coll, Sch Med, Dept Haematol, London, England

来源：

NEUROREPORT | 1999年 / 10卷 / 06期

关键词：

CBP co-activator; nerve growth factor; p42/p44 MAP kinase; Signal transduction; transcriptional regulation;

D O I：

10.1097/00001756-199904260-00016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE ability of the CBP (CREB binding protein) coactivator to stimulate transcription has previously been shown to be stimulated by treatment of neuronal cells with nerve growth factor (NGF). This effect is dependent upon activation of the p42/p44 MAPK (mitogen activated protein kinase) pathway. Here we show that both CBP and the related p300 protein directly associate with the p42/p44 MAPK enzymes both prior to and following their activation by NGF and that CBP is phosphorylated following NGF treatment. These results indicate that phosphorylation of CBP itself by the p42/p44 MAPK pathway is likely to be critical for its role in NGF-mediated stimulation of gene expression. (C) 1999 Lippincott Williams & Wilkins.

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页码：1239 / 1243

页数：5

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