Systems medicine and integrated care to combat chronic noncommunicable diseases

被引：145

作者：

Bousquet, Jean ^{[1
]}

Anto, Josep M. ^{[2
]}

Sterk, Peter J. ^{[3
]}

Adcock, Ian M. ^{[4
]}

Chung, Kian Fan ^{[5
]}

Roca, Josep ^{[6
]}

Agusti, Alvar ^{[6
]}

Brightling, Chris ^{[7
]}

Cambon-Thomsen, Anne ^{[8
]}

Cesario, Alfredo ^{[9
]}

Abdelhak, Sonia ^{[10
]}

Antonarakis, Stylianos E. ^{[11
]}

Avignon, Antoine ^{[12
]}

Ballabio, Andrea ^{[13
]}

Baraldi, Eugenio ^{[14
]}

Baranov, Alexander ^{[15
]}

Bieber, Thomas ^{[16
]}

Bockaert, Joel ^{[17
]}

Brahmachari, Samir ^{[18
]}

Brambilla, Christian ^{[19
]}

Bringer, Jacques ^{[20
]}

Dauzat, Michel ^{[21
]}

Ernberg, Ingemar ^{[22
]}

Fabbri, Leonardo ^{[23
]}

Froguel, Philippe ^{[24
]}

Galas, David ^{[25
]}

Gojobori, Takashi ^{[26
]}

Hunter, Peter ^{[27
]}

Jorgensen, Christian ^{[28
,29
]}

Kauffmann, Francine ^{[30
]}

Kourilsky, Philippe ^{[31
]}

Kowalski, Marek L. ^{[32
]}

Lancet, Doron ^{[33
]}

Le Pen, Claude ^{[34
]}

Mallet, Jacques ^{[35
]}

Mayosi, Bongani ^{[36
,37
]}

Mercier, Jacques ^{[38
]}

Metspalu, Andres ^{[39
]}

Nadeau, Joseph H. ^{[25
]}

Ninot, Gregory ^{[40
]}

Noble, Denis ^{[41
]}

Ozturk, Mehmet ^{[42
]}

Palkonen, Susanna ^{[43
,44
]}

Prefaut, Christian ^{[38
]}

Rabe, Klaus ^{[45
]}

Renard, Eric ^{[20
]}

Roberts, Richard G. ^{[46
]}

Samolinski, Boleslav ^{[47
]}

Schuenemann, Holger J. ^{[48
,49
]}

Simon, Hans-Uwe ^{[50
]}

机构：

[1] CHU Montpellier, Dept Resp Dis, Arnaud de Villeneuve Hosp, INSERM CESP U1018, Villejuif, France

[2] Univ Pompeu Fabra, Ctr Res Environm Epidemiol, Municipal Inst Med Res Epidemiol & Salud Publ, E-08003 Barcelona, Spain

[3] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands

[4] Univ London Imperial Coll Sci Technol & Med, London SW7 2AZ, England

[5] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW7 2AZ, England

[6] Univ Barcelona, Inst Clin Torax, Hosp Clin, IDIBAPS,CIBERES, E-08007 Barcelona, Spain

[7] Univ Leicester, Dept Infect Immun & Inflammat, Leicester LE1 9HN, Leics, England

[8] INSERM U558, Toulouse, France

[9] IRCCS San Raffaele, Rome, Italy

[10] Inst Pasteur, Tunis 71843755, Tunisia

[11] Univ Geneva, Sch Med, Div Med Genet, CH-1211 Geneva 4, Switzerland

[12] Dept Diabetol, Montpellier, France

[13] Telethon Inst Genom & Med, I-80131 Naples, Italy

[14] Univ Padua, Dept Pediat, I-35128 Padua, Italy

[15] Russian Acad Med Sci, Sci Ctr Childrens Hlth, Moscow 117963, Russia

[16] Univ Bonn, Dept Dermatol & Allergy, D-53105 Bonn, Germany

[17] Univ Montpellier 1&2, Inst Genom Fonct, CNRS, INSERM,U661,UMR 5203, Montpellier, France

[18] Inst Genom & Integrat Biol, Delhi 110007, India

[19] Albert Michallon Univ Hosp, Div Pulm, Albert Bonniot Canc Res Inst, Grenoble, France

[20] Lapeyronie Hosp, Montpellier, France

[21] Nimes Univ Hosp, Dept Physiol, F-30029 Nimes 9, France

[22] Karolinska Inst, Dept Microbiol Tumour & Cell Biol, SE-17177 Stockholm, Sweden

[23] Univ Modena & Regio Emilia, Dept Med & Surg Specialties, Modena, Italy

[24] Univ London Imperial Coll Sci Technol & Med, London, England

[25] Inst Syst Biol, Seattle, WA 98109 USA

[26] Natl Inst Genet, Mishima, Shizuoka 411, Japan

[27] Univ Auckland, Auckland Bioengn Inst, Auckland 1010, New Zealand

[28] Clin Unit Osteoarticular Dis, Montpellier, France

[29] INSERM U844, Montpellier, France

[30] INSERM U1018, Ctr Res Epidemiol & Populat Hlth, Villejuif, France

[31] Singapore Immunol Network, Singapore 138648, Singapore

[32] Med Univ Lodz, Lodz, Poland

[33] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

[34] Univ Paris 09, Paris, France

[35] IRCM, Paris, France

[36] Groote Schuur Hosp, Dept Med, Cape Town, South Africa

[37] Univ Cape Town, ZA-7700 Rondebosch, South Africa

[38] Univ Montpellier, Dept Physiol, Montpellier, France

[39] Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia

[40] Epsylon, Montpellier, France

[41] Univ Oxford, Dept Physiol, Oxford OX1 3QX, England

[42] Bilkent Univ, Fac Sci, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey

[43] EPF, Brussels, Belgium

[44] European Federat Allergy & Airways Dis Patients A, Brussels, Belgium

[45] Univ Kiel, Dept Med, Kiel, Germany

[46] Univ Wisconsin, Dept Family Med, Madison, WI 53715 USA

[47] Dept Publ Hlth, PL-02001 Warsaw, Poland

[48] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON L8S 4K1, Canada

[49] McMaster Univ, Dept Med, Hamilton, ON L8S 4K1, Canada

[50] Univ Bern, Inst Pharmacol, CH-3010 Bern, Switzerland

来源：

GENOME MEDICINE | 2011年 / 3卷

关键词：

CORONARY-HEART-DISEASE; QUALITY-OF-CARE; SOCIAL DETERMINANTS; PUBLIC-HEALTH; SEVERE ASTHMA; PREVALENCE; GUIDELINES; SCIENCE; INTERVENTION; COMORBIDITY;

D O I：

10.1186/gm259

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems.

引用

页数：12

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