Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence From 421,000 Participants in Two Cohorts

Individuals with low cardiovascular risk factor profiles experience lower rates of cardiovascular diseases, but associations with geriatric syndromes are unclear. We tested whether individuals with low cardiovascular disease risk, aged 6069 years old at baseline in two large cohorts, were less likely to develop aging-related adverse health outcomes. Data were from population representative medical records (Clinical Practice Research Datalink [CPRD] England, n = 239,591) and healthy volunteers (UK Biobank [UKB], n = 181,820), followed for 10 years. A cardiovascular disease risk score (CRS) summarized smoking status, LDL-cholesterol, blood pressure, body mass index, fasting glucose and physical activity, grouping individuals as low (ie, all factors near ideal), moderate, or high CRS. Logistic regression, Cox models, and Fine and Grey risk models tested the associations between the CRS and health outcomes. Low CRS individuals had less chronic pain (UKB: baseline odds ratio = 0.52, confidence interval [CI] = 0.500.54), lower incidence of incontinence (CPRD: subhazard ratio [sub-HR] = 0.75, 0.630.91), falls (sub-HR = 0.82, CI = 0.730.91), fragility fractures (sub-HR = 0.78, CI = 0.650.93), and dementia (vs. high risks; UKB: sub-HR = 0.67, CI = 0.500.89; CPRD: sub-HR = 0.79, CI = 0.561.12). Only 5.4% in CPRD with low CRS became frail (Rockwood index) versus 24.2% with high CRS. All-cause mortality was markedly lower in the low CRS group (vs. high CRS; HR = 0.40, 95% CI = 0.350.47). All associations showed doseresponse relationships, and results were similar in both cohorts. Persons aged 6069 years with near-ideal cardiovascular risk factor profiles have substantially lower incidence of geriatric conditions and frailty. Optimizing cardiovascular disease risk factors may substantially reduce the burden of morbidity in later life.