Induction of heterosynaptic and homosynaptic LTD in hippocampal sub-regions in vivo

被引：14

作者：

Abraham, WC ^{[1
]}

机构：

[1] UNIV OTAGO,CTR RES NEUROSCI,DUNEDIN,NEW ZEALAND

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1996年 / 90卷 / 5-6期

关键词：

long-term depression (LTD); synaptic plasticity; dentate gyrus; NMDA receptor; anesthetized preparation; low-frequency stimulation;

D O I：

10.1016/S0928-4257(97)87902-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Establishing the conditions under which long-term depression (LTD) can be induced in vitro remains an important empirical issue. While heterosynaptic LTD is readily elicited in the hippocampus in vivo, the induction of homosynaptic LTD has been more problematic, both in CA1 and in the dentate gyrus. Our work has demonstrated, however, that 900 pulses at 1 Hz will reliably induce LTD in both area CA1 and the dentate gyrus of pentobarbital-anesthetized animals, when the stimulating and recording electrodes are in close proximity to each other.

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收藏

页码：305 / 306

页数：2

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