Genetics - Engineering a broken heart

被引：3

作者：

Scambler, PJ ^{[1
]}

机构：

[1] Inst Child Hlth, Mol Med Unit, London WC1N 1EH, England

来源：

NATURE | 1999年 / 401卷 / 6751期

关键词：

D O I：

10.1038/43804

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many birth defects are caused by chromosomal insertions or deletions. The most common deletion syndrome in humans is DiGeorge syndrome, one of the symptoms of which is congenital heart disease. DiGeorge syndrome was thought to be caused by deletion of just one gene, but the results of a targeted-deletion study indicate that more than one gene is likely to be affected.

引用

页码：335 / 337

页数：3

共 12 条

[1]

Emanuel B. S., 1998, HEART DEV, P463

[2] The gene encoding proline dehydrogenase modulates sensorimotor gating in mice [J].

Gogos, JA ;

Santha, M ;

Takacs, Z ;

Beck, KD ;

Luine, V ;

Lucas, LR ;

Nadler, JV ;

Karayiorgou, M .

NATURE GENETICS, 1999, 21 (04) :434-439

[3] SCHIZOPHRENIA SUSCEPTIBILITY ASSOCIATED WITH INTERSTITIAL DELETIONS OF CHROMOSOME 22Q11 [J].

KARAYIORGOU, P ;

MORRIS, MA ;

MORROW, B ;

SHPRINTZEN, RJ ;

GOLDBERG, R ;

BORROW, J ;

GOS, A ;

NESTADT, G ;

WOLYNIEC, PS ;

LASSETER, VK ;

EISEN, H ;

CHILDS, B ;

KAZAZIAN, HH ;

KUCHERLAPATI, R ;

ANTONARAKIS, SE ;

PULVER, AE ;

HOUSMAN, DE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7612-7616

[4]

KIMBER W, IN PRESS HUM MOL GEN

[5] NEURAL CREST AND CARDIOVASCULAR PATTERNING [J].

KIRBY, ML ;

WALDO, KL .

CIRCULATION RESEARCH, 1995, 77 (02) :211-215

[6] Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1 [J].

Li, LH ;

Krantz, ID ;

Deng, Y ;

Genin, A ;

Banta, AB ;

Collins, CC ;

Qi, M ;

Trask, BJ ;

Kuo, WL ;

Cochran, J ;

Costa, T ;

Pierpont, MEM ;

Rand, EB ;

Piccoli, DA ;

Hood, L ;

Spinner, NB .

NATURE GENETICS, 1997, 16 (03) :243-251

[7] Congenital heart disease in mice deficient for the DiGeorge syndrome region [J].

Lindsay, EA ;

Botta, A ;

Jurecic, V ;

Carattini-Rivera, S ;

Cheah, YC ;

Rosenblatt, HM ;

Bradley, A ;

Baldini, A .

NATURE, 1999, 401 (6751) :379-383

[8] Sequence-ready physical map of the mouse Chromosome 16 region with conserved synteny to the human Velocardiofacial syndrome region on 22q11.2 [J].

Lund, J ;

Roe, B ;

Chen, F ;

Budarf, M ;

Galili, N ;

Riblet, R ;

Miller, RD ;

Emanuel, BS ;

Reeves, RH .

MAMMALIAN GENOME, 1999, 10 (05) :438-443

[9] A novel 22q11.2 microdeletion in DiGeorge syndrome [J].

Rauch, A ;

Pfeiffer, RA ;

Leipold, G ;

Singer, H ;

Tigges, M ;

Hofbeck, M .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 64 (02) :659-667

[10]

Sutherland HF, 1996, AM J HUM GENET, V59, P23

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