Pharmacokinetics of daptomycin in a critically ill adolescent with vancomycin-resistant enterococcal endocarditis

被引:21
作者
Akins, RL
Haase, MR
Levy, EN
机构
[1] Texas Tech Univ, Hlth Sci Ctr, Sch Pharm, Dept Pharm Practice, Amarillo, TX 79106 USA
[2] Texas Tech Univ, Hlth Sci Ctr, Sch Med, Amarillo, TX 79106 USA
来源
PHARMACOTHERAPY | 2006年 / 26卷 / 05期
关键词
daptomycin; pharmacokinetics; children; endocarditis; enterococci;
D O I
10.1592/phco.26.5.694
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Daptomycin is a lipopeptide antibiotic active against multidrug-resistant gram-positive organisms. Our search of the literature found no published pediatric pharmacokinetic data. We report the use and pharmacokinetic analysis of daptomycin in a 13-year-old boy with vancomycin-resistant Enterococcus faecium endocarditis. Pharmacokinetic parameters were found to be significantly different from published adult parameters, such as a faster elimination rate, shorter half-life, and increased clearance. These age-related differences in the pharmacokinetic profile of daptomycin have significant dosing implications. As the use of this drug for off-label indications and in pediatric populations increases, it is important for clinicians to better understand the drug's pharmacokinetic profile in these patient populations.
引用
收藏
页码:694 / 698
页数:5
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