A new branch on the tree: Next-generation sequencing in the study of cancer evolution

被引：27

作者：

Brosnan, Jacqueline A. ^{[2
,3
]}

Iacobuzio-Donahue, Christine A. ^{[1
,3
,4
,5
]}

机构：

[1] Johns Hopkins Univ Hosp, Dept Pathol, GI Liver Div, Baltimore, MD 21231 USA

[2] Johns Hopkins Med Inst, Grad Program Pathobiol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA

[3] Johns Hopkins Med Inst, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA

[4] Johns Hopkins Med Inst, Dept Oncol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA

[5] Johns Hopkins Med Inst, Dept Surg, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2012年 / 23卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Next-generation sequencing; Metastasis; Clonal evolution; High throughput; CLONAL EVOLUTION; CHROMOSOMAL ALTERATIONS; GENETIC-HETEROGENEITY; COPY-NUMBER; BREAST; METASTASIS; CELLS; CARCINOMAS; MUTATIONS; REVEALS;

D O I：

10.1016/j.semcdb.2011.12.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer is a disease caused by the accumulation of genetic alterations in association with successive waves of clonal expansion. Mapping of the human genome sequence, in conjunction with technical advances in the ability to sequence entire genomes, have provided new insight into the mutational spectra and genetic events associated with clonal evolution of cancer. Moving forward, a clearer understanding of those alterations that undergo positive and negative selection throughout carcinogenesis and leading to metastatic dissemination would provide a boon not only to our understanding of cancer evolution, but to the development of potential targets for therapeutic intervention as well. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：237 / 242

页数：6

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