Exposing the exposures responsible for type 2 diabetes and obesity

被引：266

作者：

Franks, Paul W. ^{[1
,2
,3
]}

McCarthy, Mark I. ^{[4
,5
]}

机构：

[1] Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden

[2] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[3] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[4] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England

[5] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England

来源：

SCIENCE | 2016年 / 354卷 / 6308期

基金：

美国国家卫生研究院; 英国医学研究理事会; 瑞典研究理事会; 英国惠康基金;

关键词：

BODY-MASS INDEX; GENE-ENVIRONMENT INTERACTIONS; BIRTH-WEIGHT; INTESTINAL MICROBIOTA; WIDE ASSOCIATION; DNA METHYLATION; METAANALYSIS; VARIANTS; GENOME; PREDISPOSITION;

D O I：

10.1126/science.aaf5094

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The rising prevalences of type 2 diabetes and obesity constitutemajor threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced throughout the life course. Although "Western" lifestyle represents a convenient catch-all culprit for such exposures, effective treatment and prevention will be informed by characterization of the most critical, causal environmental factors. In this Review, we examine how burgeoning understanding of the genetic basis of type 2 diabetes and obesity can highlight nongenetic exposures that drive development of these conditions.

引用

页码：69 / 73

页数：5

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