Transferable hyperproduction of TEM-1 beta-lactamase in Shigella flexneri due to a point mutation in the pribnow box

被引：35

作者：

Siu, LK ^{[1
]}

Ho, PL ^{[1
]}

Yuen, KY ^{[1
]}

Wong, SSY ^{[1
]}

Chau, PY ^{[1
]}

机构：

[1] UNIV HONG KONG,DEPT MICROBIOL,HONG KONG,HONG KONG

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 02期

关键词：

D O I：

10.1128/AAC.41.2.468

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

TEM-1 hyperproduction in two ampicillin-sulbactam-resistant Shigella flexneri strains was studied, In both strains the bla(TEM) gene was encoded as a single copy on a large conjugatively transferable plasmid, A single G-->T transversion at position 1 of the -10 consensus sequence was identified to be the mechanism of TEM-1 hyperproduction.

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收藏

页码：468 / 470

页数：3

相关论文

共 21 条

[1] A FUNCTIONAL CLASSIFICATION SCHEME FOR BETA-LACTAMASES AND ITS CORRELATION WITH MOLECULAR-STRUCTURE [J].

BUSH, K ;

JACOBY, GA ;

MEDEIROS, AA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (06) :1211-1233

[2] EXPRESSION OF MALT, THE REGULATOR GENE OF THE MALTOSE REGULON IN ESCHERICHIA-COLI, IS LIMITED BOTH AT TRANSCRIPTION AND TRANSLATION [J].

CHAPON, C .

EMBO JOURNAL, 1982, 1 (03) :369-374

[3] 2 IMPROVED PROMOTER SEQUENCES FOR THE BETA-LACTAMASE EXPRESSION ARISING FROM A SINGLE BASE-PAIR SUBSTITUTION [J].

CHEN, ST ;

CLOWES, RC .

NUCLEIC ACIDS RESEARCH, 1984, 12 (07) :3219-3234

[4] A GENE PROBE FOR TEM TYPE BETA-LACTAMASES [J].

COOKSEY, RC ;

CLARK, NC ;

THORNSBERRY, C .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 28 (01) :154-156

[5] KLEBSIELLA-OXYTOCA - RESISTANCE TO AZTREONAM BY OVERPRODUCTION OF THE CHROMOSOMALLY ENCODED BETA-LACTAMASE [J].

FOURNIER, B ;

ARLET, G ;

LAGRANGE, PH ;

PHILIPPON, A .

FEMS MICROBIOLOGY LETTERS, 1994, 116 (01) :31-36

[6] POINT MUTATION IN THE PRIBNOW BOX, THE MOLECULAR-BASIS OF BETA-LACTAMASE OVERPRODUCTION IN KLEBSIELLA-OXYTOCA [J].

FOURNIER, B ;

LU, CY ;

LAGRANGE, PH ;

KRISHNAMOORTHY, R ;

PHILIPPON, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (06) :1365-1368

[7] beta-Lactamase gene promoters of 71 clinical strains of Klebsiella oxytoca [J].

Fournier, B ;

Lagrange, PH ;

Philippon, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (02) :460-463

[8] SEQUENCE OF THE GENES BLAT-1B AND BLAT-2 [J].

GOUSSARD, S ;

COURVALIN, P .

GENE, 1991, 102 (01) :71-73

[9] COMPILATION AND ANALYSIS OF ESCHERICHIA-COLI PROMOTER DNA-SEQUENCES [J].

HAWLEY, DK ;

MCCLURE, WR .

NUCLEIC ACIDS RESEARCH, 1983, 11 (08) :2237-2255

[10] SEQUENCE ELEMENTS DETERMINING AMPC PROMOTER STRENGTH IN ESCHERICHIA-COLI [J].

JAURIN, B ;

GRUNDSTROM, T ;

NORMARK, S .

EMBO JOURNAL, 1982, 1 (07) :875-881