Comparison of Preincisional and Postincisional Parecoxib Administration on Postoperative Pain Control and Cytokine Response After Total Hip Replacement

被引:24
作者
Bao, Y. [2 ]
Fang, J. [1 ]
Peng, L. [3 ]
Yi, Y. [3 ]
Liu, K. [3 ]
Li, W. [3 ]
Luo, H. [3 ]
机构
[1] Second Peoples Hosp Jingzhou, Dept Neurol, Jinzhou 434000, Hubei, Peoples R China
[2] Yangtze Univ, Sch Med, Dept Orthopaed, Jinzhou, Hubei, Peoples R China
[3] First Peoples Hosp Jingzhou, Dept Orthopaed, Jinzhou, Hubei, Peoples R China
关键词
PARECOXIB; CYCLO-OXYGENASE-2; INHIBITOR; TOTAL HIP REPLACEMENT; PREINCISIONAL ANALGESIA; PAIN; CYTOKINE RESPONSE; NECROSIS-FACTOR-ALPHA; PREEMPTIVE ANALGESIA; TNF-ALPHA; CYCLOOXYGENASE-2; INTERLEUKIN-6; SURGERY; INFLAMMATION; EXPRESSION; IL-1-BETA; TRAUMA;
D O I
10.1177/030006051204000518
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
100103 [病原生物学]; 100218 [急诊医学];
摘要
OBJECTIVE: To investigate whether preincisional parecoxib administration can reduce postoperative pain and modulate the inflammatory cytokine response to a greater extent than preincisional parecoxib administration in total hip replacement patients. METHODS: Patients were randomized to receive 40 mg parecoxib intravenously either before or after skin incision (preincisional and postincisional groups, respectively). Morphine was administered for postoperative analgesia. Visual analogue pain scale (VAS) scores and morphine consumption were recorded at 1, 6, 18 and 24 h postoperation. Plasma levels of interleukin (IL)-6, IL-8 and tumour necrosis factor-a were measured 30 min before skin incision and 6 h postoperation. RESULTS: Compared with the postincisional group, VAS pain scores at 1 and 6 h postoperation were significantly lower in the preincisional group. Morphine consumption was significantly lower in the preincisional group at 6, 18 and 24 h postoperation. In both groups, IL-6 and IL-8 levels increased significantly at 6 h postoperation compared with pre-operation, and the preincisional group had significantly lower levels of IL-6 and IL-8 at 6 h postoperation compared with the postincisional group. CONCLUSIONS: Preincisional parecoxib administration reduced postoperative pain and morphine consumption compared with postincisional administration, and attenuated IL-6 and IL-8 production 24 h after hip replacement surgery.
引用
收藏
页码:1804 / 1811
页数:8
相关论文
共 29 条
[1]
Bajaj P, 2004, J Indian Med Assoc, V102, P276
[2]
Bajaj P, 2004, J INDIAN MED ASSOC, V102, P274
[3]
Bajaj P, 2004, J INDIAN MED ASSOC, V274, P276
[4]
Effects of preemptive analgesia on pain and cytokine production in the postoperative period [J].
Beilin, B ;
Bessler, H ;
Mayburd, E ;
Smirnov, G ;
Dekel, A ;
Yardeni, I ;
Shavit, Y .
ANESTHESIOLOGY, 2003, 98 (01) :151-155
[5]
Systemic cytokine response after emergency and elective surgery for colorectal carcinoma [J].
Catena, Fausto ;
Ansaloni, Luca ;
Avanzolini, Andrea ;
Di Saverio, Salomone ;
D'Alessandro, Luigi ;
Casadei, Mario Maldini ;
Pinna, Antonio .
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2009, 24 (07) :803-808
[6]
RESPONSE OF SERUM INTERLEUKIN-6 IN PATIENTS UNDERGOING ELECTIVE SURGERY OF VARYING SEVERITY [J].
CRUICKSHANK, AM ;
FRASER, WD ;
BURNS, HJG ;
VANDAMME, J ;
SHENKIN, A .
CLINICAL SCIENCE, 1990, 79 (02) :161-165
[7]
INTERLEUKIN-8 AS A MEDIATOR OF SYMPATHETIC PAIN [J].
CUNHA, FQ ;
LORENZETTI, BB ;
POOLE, S ;
FERREIRA, SH .
BRITISH JOURNAL OF PHARMACOLOGY, 1991, 104 (03) :765-767
[8]
The stress response to trauma and surgery [J].
Desborough, JP .
BRITISH JOURNAL OF ANAESTHESIA, 2000, 85 (01) :109-117
[9]
Effects of a selective cyclooxygenase-2 inhibitor on postoperative inflammatory reaction and pain after total knee replacement [J].
Feng, Yi ;
Ju, Hui ;
Yang, Baxian ;
An, Haiyan .
JOURNAL OF PAIN, 2008, 9 (01) :45-52
[10]
The Role of the Perioperative Period in Recurrence After Cancer Surgery [J].
Gottschalk, Antje ;
Sharma, Sonal ;
Ford, Justin ;
Durieux, Marcel E. ;
Tiouririne, Mohamed .
ANESTHESIA AND ANALGESIA, 2010, 110 (06) :1636-1643