Novel pH-responsive nanoparticles

被引：48

作者：

Filippov, Sergey ^{[1
]}

Hruby, Martin ^{[1
]}

Konak, Cestmir ^{[1
]}

Mackova, Hana ^{[1
]}

Spirkova, Milena ^{[1
]}

Stepanek, Petr ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Macromol Chem, Prague 16206 6, Czech Republic

来源：

LANGMUIR | 2008年 / 24卷 / 17期

关键词：

D O I：

10.1021/la801472x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work we report a new type of pH-responsive micelle-like nanoparticle. Reversible nanoscale structures are formed in solutions of a pH-sensitive hydrophobic polyelectrolyte, poly(N-methacryloyl-L-valine) or poly(N-methacryloyl-L-phenylalanine), and nonionic surfactant (Brij 98) in the presence of hydrochloric acid. The influence of composition and pH on particles size and shape was investigated by a variety of methods. An entity's size and polydispersity could be varied in a broad range making them a perspective candidate as a drug carrier. Unlike the case of typical micelles, our results indicate the presence of cavities in the formed particles. A hypothetical model of a nanoparticle and mechanism of formation are proposed.

引用

页码：9295 / 9301

页数：7

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