Mechanisms of chronic hypoxia-induced renal cell growth

被引：43

作者：

Sahai, A

Mei, CL

Schrier, RW

Tannen, RL

机构：

[1] Northwestern Univ, Ctr Med, Div Nephrol & Hypertens, Chicago, IL 60611 USA

[2] Univ Colorado, Ctr Hlth Sci, Div Renal Dis & Hypertens, Denver, CO 80202 USA

[3] Univ So Calif, Sch Med, Dept Med, Los Angeles, CA USA

来源：

KIDNEY INTERNATIONAL | 1999年 / 56卷 / 04期

关键词：

blood flow; oxygen delivery; progressive glomerular disease; hypertension; glomerular sclerosis;

D O I：

10.1046/j.1523-1755.1999.00703.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic local tissue hypoxia appears to play an important role in the initiation and progression of chronic renal disease. We examined the effect of local hypoxia on cultured renal tubular epithelial and mesangial cell proliferation, dedifferentiation, and extracellular matrix synthesis. The underlying signaling mechanisms whereby hypoxia induces renal cell growth were evaluated. The roles of protein kinase C, p38 mitogen-activated protein kinase, TGF-beta 1, osteopontin, and nitric oxide were determined.

引用

页码：1277 / 1281

页数：5

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