Kinetics of serological responses in influenza A(H7N9)-infected patients correlate with clinical outcome in China, 2013

被引：30

作者：

Zhang, A. ^{[1
,2
,3
]}

Huang, Y. ^{[1
,2
,3
]}

Tian, D. ^{[1
,2
,3
]}

Lau, E. H. ^{[3
]}

Wan, Y. ^{[1
,2
,3
]}

Liu, X. ^{[1
,2
,3
]}

Dong, Y. ^{[1
,2
]}

Song, Z. ^{[1
,2
]}

Zhang, X. ^{[1
,2
]}

Zhang, J. ^{[1
,2
]}

Bao, M. ^{[1
,2
]}

Zhou, M. ^{[1
,2
]}

Yuan, S. ^{[1
,2
]}

Sun, J. ^{[1
,2
]}

Zhu, Z. ^{[1
,2
]}

Hu, Y. ^{[1
,2
]}

Chen, L. ^{[1
,2
]}

Leung, C. Y.

Wu, J. T.

Zhang, Z. ^{[1
,2
]}

Zhang, Xiaoyan ^{[2
,4
]}

Peiris, J. S.

Xu, J. ^{[1
,2
,4
]}

机构：

[1] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai 200433, Peoples R China

[2] Fudan Univ, Inst Biomed Sci, Key Lab Med Mol Virol, Minist Educ Hlth,Shanghai Med Coll, Shanghai 200433, Peoples R China

[3] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China

[4] CDC, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China

来源：

EUROSURVEILLANCE | 2013年 / 18卷 / 50期

关键词：

A H7N9 VIRUS; HUMAN INFECTIONS; ANTIBODIES; HUMANS;

D O I：

10.2807/1560-7917.ES2013.18.50.20657

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The novel avian influenza A(H7N9) infection has recently emerged to cause severe respiratory illness in China. The objectives of this study were to define the kinetics of the antibody responses in patients with influenza A(H7N9) disease and to correlate these kinetics with clinical outcome. Serial serum samples were obtained at intervals of three to four days from 18 patients with virologically confirmed A(H7N9) disease in Shanghai. We determined the kinetics of the haemagglutination inhibition (HI) and A(H7H9) pseudo-type neutralisation antibody (Nab) responses and correlated these with clinical outcomes. Most patients had robust serological responses by both HI and Nab tests. Taking into account censoring due to time of testing and death, the median time from onset of illness to Nab titre >= 1:40 was 14 days (95% confidence interval (CI): 11-18 days) in the fatal cases and 10.5 days (95% CI: 7-12) in the survivors (p=0.003). The two groups did not differ in initial Nab titres, but the rate of increase in Nab titres was significantly faster for survivors by approximately 10-fold per 15 days (p=0.007). Early and rapid induction of Nab was correlated significantly with better clinical outcome.

引用

页码：38 / 45

页数：8

共 18 条

[1] Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus [J].

Baskin, Carole R. ;

Bielefeldt-Ohmann, Helle ;

Tumpey, Terrence M. ;

Sabourin, Patrick J. ;

Long, James P. ;

Garcia-Sastre, Adolfo ;

Tolnay, Airn-E. ;

Albrecht, Randy ;

Pyles, John A. ;

Olson, Pam H. ;

Aicher, Lauri D. ;

Rosenzweig, Elizabeth R. ;

Murali-Krishna, Kaja ;

Clark, Edward A. ;

Kotur, Mark S. ;

Fornek, Jamie L. ;

Proll, Sean ;

Palermo, Robert E. ;

Sabourin, Carol L. ;

Katze, Michael G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (09) :3455-3460

[2]

Centers for Disease Control and Prevention (CDC), MOD HEM INH HI ASS U

[3] Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases [J].

Cowling, Benjamin J. ;

Jin, Lianmei ;

Lau, Eric H. Y. ;

Liao, Qiaohong ;

Wu, Peng ;

Jiang, Hui ;

Tsang, Tim K. ;

Zheng, Jiandong ;

Fang, Vicky J. ;

Chang, Zhaorui ;

Ni, Michael Y. ;

Zhang, Qian ;

Ip, Dennis K. M. ;

Yu, Jianxing ;

Li, Yu ;

Wang, Liping ;

Tu, Wenxiao ;

Meng, Ling ;

Wu, Joseph T. ;

Luo, Huiming ;

Li, Qun ;

Shu, Yuelong ;

Li, Zhongjie ;

Feng, Zijian ;

Yang, Weizhong ;

Wang, Yu ;

Leung, Gabriel M. ;

Yu, Hongjie .

LANCET, 2013, 382 (9887) :129-137

[4] Clinical Findings in 111 Cases of Influenza A (H7N9) Virus Infection [J].

Gao, Hai-Nv ;

Lu, Hong-Zhou ;

Cao, Bin ;

Du, Bin ;

Shang, Hong ;

Gan, Jian-He ;

Lu, Shui-Hua ;

Yang, Yi-Da ;

Fang, Qiang ;

Shen, Yin-Zhong ;

Xi, Xiu-Ming ;

Gu, Qin ;

Zhou, Xian-Mei ;

Qu, Hong-Ping ;

Yan, Zheng ;

Li, Fang-Ming ;

Zhao, Wei ;

Gao, Zhan-Cheng ;

Wang, Guang-Fa ;

Ruan, Ling-Xiang ;

Wang, Wei-Hong ;

Ye, Jun ;

Cao, Hui-Fang ;

Li, Xing-Wang ;

Zhang, Wen-Hong ;

Fang, Xu-Chen ;

He, Jian ;

Liang, Wei-Feng ;

Xie, Juan ;

Zeng, Mei ;

Wu, Xian-Zheng ;

Li, Jun ;

Xia, Qi ;

Jin, Zhao-Chen ;

Chen, Qi ;

Tang, Chao ;

Zhang, Zhi-Yong ;

Hou, Bao-Min ;

Feng, Zhi-Xian ;

Sheng, Ji-Fang ;

Zhong, Nan-Shan ;

Li, Lan-Juan .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (24) :2277-2285

[5] Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus [J].

Gao, Rongbao ;

Cao, Bin ;

Hu, Yunwen ;

Feng, Zijian ;

Wang, Dayan ;

Hu, Wanfu ;

Chen, Jian ;

Jie, Zhijun ;

Qiu, Haibo ;

Xu, Ke ;

Xu, Xuewei ;

Lu, Hongzhou ;

Zhu, Wenfei ;

Gao, Zhancheng ;

Xiang, Nijuan ;

Shen, Yinzhong ;

He, Zebao ;

Gu, Yong ;

Zhang, Zhiyong ;

Yang, Yi ;

Zhao, Xiang ;

Zhou, Lei ;

Li, Xiaodan ;

Zou, Shumei ;

Zhang, Ye ;

Li, Xiyan ;

Yang, Lei ;

Guo, Junfeng ;

Dong, Jie ;

Li, Qun ;

Dong, Libo ;

Zhu, Yun ;

Bai, Tian ;

Wang, Shiwen ;

Hao, Pei ;

Yang, Weizhong ;

Zhang, Yanping ;

Han, Jun ;

Yu, Hongjie ;

Li, Dexin ;

Gao, George F. ;

Wu, Guizhen ;

Wang, Yu ;

Yuan, Zhenghong ;

Shu, Yuelong .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (20) :1888-1897

[6] Optimization and evaluation of an influenza A (H5) pseudotyped lentiviral particle-based serological assay [J].

Garcia, Jean-Michel ;

Lagarde, Nadege ;

Ma, Edward S. K. ;

de Jong, Menno D. ;

Peiris, J. S. Malik .

JOURNAL OF CLINICAL VIROLOGY, 2010, 47 (01) :29-33

[7] Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance [J].

Hu, Yunwen ;

Lu, Shuihua ;

Song, Zhigang ;

Wang, Wei ;

Hao, Pei ;

Li, Jianhua ;

Zhang, Xiaonan ;

Yen, Hui-Ling ;

Shi, Bisheng ;

Li, Tao ;

Guan, Wencai ;

Xu, Lei ;

Liu, Yi ;

Wang, Sen ;

Zhang, Xiaoling ;

Tian, Di ;

Zhu, Zhaoqin ;

He, Jing ;

Huang, Kai ;

Chen, Huijie ;

Zheng, Lulu ;

Li, Xuan ;

Ping, Jie ;

Kang, Bin ;

Xi, Xiuhong ;

Zha, Lijun ;

Li, Yixue ;

Zhang, Zhiyong ;

Peiris, Malik ;

Yuan, Zhenghong .

LANCET, 2013, 381 (9885) :2273-2279

[8] Convalescent Plasma Treatment Reduced Mortality in Patients With Severe Pandemic Influenza A (H1N1) 2009 Virus Infection [J].

Hung, Ivan F. N. ;

To, Kelvin K. W. ;

Lee, Cheuk-Kwong ;

Lee, Kar-Lung ;

Chan, Kenny ;

Yan, Wing-Wah ;

Liu, Raymond ;

Watt, Chi-Leung ;

Chan, Wai-Ming ;

Lai, Kang-Yiu ;

Koo, Chi-Kwan ;

Buckley, Tom ;

Chow, Fu-Loi ;

Wong, Kwan-Keung ;

Chan, Hok-Sum ;

Ching, Chi-Keung ;

Tang, Bone S. F. ;

Lau, Candy C. Y. ;

Li, Iris W. S. ;

Liu, Shao-Haei ;

Chan, Kwok-Hung ;

Lin, Che-Kit ;

Yuen, Kwok-Yung .

CLINICAL INFECTIOUS DISEASES, 2011, 52 (04) :447-456

[9] The genesis and source of the H7N9 influenza viruses causing human infections in China [J].

Lam, Tommy Tsan-Yuk ;

Wang, Jia ;

Shen, Yongyi ;

Zhou, Boping ;

Duan, Lian ;

Cheung, Chung-Lam ;

Ma, Chi ;

Lycett, Samantha J. ;

Leung, Connie Yin-Hung ;

Chen, Xinchun ;

Li, Lifeng ;

Hong, Wenshan ;

Chai, Yujuan ;

Zhou, Linlin ;

Liang, Huyi ;

Ou, Zhihua ;

Liu, Yongmei ;

Farooqui, Amber ;

Kelvin, David J. ;

Poon, Leo L. M. ;

Smith, David K. ;

Pybus, Oliver G. ;

Leung, Gabriel M. ;

Shu, Yuelong ;

Webster, Robert G. ;

Webby, Richard J. ;

Peiris, Joseph S. M. ;

Rambaut, Andrew ;

Zhu, Huachen ;

Guan, Yi .

NATURE, 2013, 502 (7470) :241-+

[10] Epidemiology of Human Infections with Avian Influenza A(H7N9) Virus in China [J].

Li, Qun ;

Zhou, Lei ;

Zhou, Minghao ;

Chen, Zhiping ;

Li, Furong ;

Wu, Huanyu ;

Xiang, Nijuan ;

Chen, Enfu ;

Tang, Fenyang ;

Wang, Dayan ;

Meng, Ling ;

Hong, Zhiheng ;

Tu, Wenxiao ;

Cao, Yang ;

Li, Leilei ;

Ding, Fan ;

Liu, Bo ;

Wang, Mei ;

Xie, Rongheng ;

Gao, Rongbao ;

Li, Xiaodan ;

Bai, Tian ;

Zou, Shumei ;

He, Jun ;

Hu, Jiayu ;

Xu, Yangting ;

Chai, Chengliang ;

Wang, Shiwen ;

Gao, Yongjun ;

Jin, Lianmei ;

Zhang, Yanping ;

Luo, Huiming ;

Yu, Hongjie ;

He, Jianfeng ;

Li, Qi ;

Wang, Xianjun ;

Gao, Lidong ;

Pang, Xinghuo ;

Liu, Guohua ;

Yan, Yansheng ;

Yuan, Hui ;

Shu, Yuelong ;

Yang, Weizhong ;

Wang, Yu ;

Wu, Fan ;

Uyeki, Timothy M. ;

Feng, Zijian .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (06) :520-532

← 1 2 →