Interleukin-6 production by human neonatal monocytes stimulated by type III group B streptococci

被引：22

作者：

Vallejo, JG ^{[1
]}

Baker, CJ ^{[1
]}

Edwards, MS ^{[1
]}

机构：

[1] BAYLOR COLL MED,DEPT MICROBIOL & IMMUNOL,INFECT DIS SECT,HOUSTON,TX 77030

来源：

JOURNAL OF INFECTIOUS DISEASES | 1996年 / 174卷 / 02期

关键词：

D O I：

10.1093/infdis/174.2.332

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The subcellular components of type III group B streptococci (GBS) that contribute to the host inflammatory response were determined by measuring production of the proinflammatory cytokine interleukin (IL)-6 by cord blood monocytes. Monocytes were stimulated with encapsulated (COH1) or unencapsulated (COH1-13) whole type III GBS or with purified GBS components, including type III capsular polysaccharide (III-PS), group B antigen (GB-Ag), lipoteichoic acid (LTA), or Escherichia coli lipopolysaccharide. Monocytes exposed to COH1 and COH1-13 released similar amounts of IL-6. GBS III-PS, GB-Ag, and LTA each induced IL-6. However, IL-6 release by monocytes was significantly greater after stimulation by GB-AB than by III-PS or LTA (P < .05). Sera from 16 neonates with systemic GBS disease had IL-6 levels of 8 pg/mL to 4.28 ng/mL. GB-Ag is a potent inducer of IL-6 and may play an important role in tissue inflammation during GBS infection.

引用

页码：332 / 337

页数：6

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