Characterization of duplicated zebrafish cyp19 genes

被引：69

作者：

Chiang, EFL

Yan, YL

Tong, SK

Hsiao, PH

Guiguen, Y

Postlethwait, J

Chung, BC ^{[1
]}

机构：

[1] Acad Sinica, Inst Mol Biol, Taipei 115, Taiwan

[2] Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA

[3] Natl Taiwan Univ Hosp, Dept Pediat, Taipei 10016, Taiwan

[4] INRA, SCRIBE, F-35042 Rennes, France

来源：

JOURNAL OF EXPERIMENTAL ZOOLOGY | 2001年 / 290卷 / 07期

关键词：

D O I：

10.1002/jez.1121

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

The zebrafish has recently been developed as a good genetic model system. We report here the use of zebrafish to study the regulation of estrogen biosynthesis. The CYP19 gene encodes cytochrome P450 aromatase, which catalyzes the synthesis of estrogens. Two cyp19 genes, termed cyp19a and cyp19b, have been isolated from zebrafish. Sequence comparison shows that Cyp19a and Cyp19b belong to two separate Cyp19 subfamilies. The cyp19a gene is expressed in the ovary, whereas cyp19b is expressed in the brain. The cyp19a and cyp19b genes are located on zebrafish chromosomes LG 18 and 25, respectively. Our data indicate that these gene loci arose through an ancient chromosomal duplication event. The expression of duplicated genes in distinct tissues may have evolutionary significance. J. Exp. Zool. 290:709-714, 2001. (C) 2001 Wiley-Liss, Inc.

引用

页码：709 / 714

页数：6

共 18 条

[1] Endocrine and environmental aspects of sex differentiation in fish [J].

Baroiller, JF ;

Guiguen, Y ;

Fostier, A .

CELLULAR AND MOLECULAR LIFE SCIENCES, 1999, 55 (6-7) :910-931

[2] ESTRADIOL-17-BETA ASSOCIATED WITH THE SEX REVERSAL IN PROTANDROUS BLACK PORGY, ACANTHOPAGRUS-SCHLEGELI [J].

CHANG, CF ;

LEE, MF ;

CHEN, GR .

JOURNAL OF EXPERIMENTAL ZOOLOGY, 1994, 268 (01) :53-58

[3] Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain [J].

Chiang, EFL ;

Yan, YL ;

Guiguen, Y ;

Postlethwait, J ;

Chung, BC .

MOLECULAR BIOLOGY AND EVOLUTION, 2001, 18 (04) :542-550

[4]

Gates MA, 1999, GENOME RES, V9, P334

[5] A radiation hybrid map of the zebrafish genome [J].

Geisler, R ;

Rauch, GJ ;

Baier, H ;

van Bebber, F ;

Bross, L ;

Dekens, MPS ;

Finger, K ;

Fricke, C ;

Gates, MA ;

Geiger, H ;

Geiger-Rudolph, S ;

Gilmour, D ;

Glaser, S ;

Gnügge, L ;

Habeck, H ;

Hingst, K ;

Holley, S ;

Keenan, J ;

Kirn, A ;

Knaut, H ;

Lashkari, D ;

Maderspacher, F ;

Martyn, U ;

Neuhauss, S ;

Neumann, C ;

Nicolson, T ;

Pelegri, F ;

Ray, R ;

Rick, JM ;

Roehl, H ;

Roeser, T ;

Schauerte, HE ;

Schier, AF ;

Schönberger, U ;

Schönthaler, HB ;

Schulte-Merker, S ;

Seydler, C ;

Talbot, WS ;

Weiler, C ;

Nüsslein-Volhard, C ;

Haffter, P .

NATURE GENETICS, 1999, 23 (01) :86-89

[6] IDENTIFICATION OF POLYMORPHIC SIMPLE SEQUENCE REPEATS IN THE GENOME OF THE ZEBRAFISH [J].

GOFF, DJ ;

GALVIN, K ;

KATZ, H ;

WESTERFIELD, M ;

LANDER, ES ;

TABIN, CJ .

GENOMICS, 1992, 14 (01) :200-202

[7] Radiation hybrid mapping of the zebrafish genome [J].

Hukriede, NA ;

Joly, L ;

Tsang, M ;

Miles, J ;

Tellis, P ;

Epstein, JA ;

Barbazuk, WB ;

Li, FN ;

Paw, B ;

Postlethwait, JH ;

Hudson, TJ ;

Zon, LI ;

McPherson, JD ;

Chevrette, M ;

Dawid, IB ;

Johnson, SL ;

Ekker, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) :9745-9750

[8]

Johnson SL, 1996, GENETICS, V142, P1277

[9] A microsatellite genetic linkage map for zebrafish (Danio rerio) [J].

Knapik, EW ;

Goodman, A ;

Ekker, M ;

Chevrette, M ;

Delgado, J ;

Neuhauss, S ;

Shimoda, N ;

Driever, W ;

Fishman, MC ;

Jacob, HJ .

NATURE GENETICS, 1998, 18 (04) :338-343

[10]

Knapik EW, 1996, DEVELOPMENT, V123, P451

← 1 2 →