Capillary affinity gel electrophoresis - New tool for detection of the mutation on DNA

被引：11

作者：

Baba, Y ^{[1
]}

机构：

[1] KOBE PHARMACEUT UNIV,DEPT CHEM,HIGASHINADA KU,KOBE,HYOGO 658,JAPAN

来源：

MOLECULAR BIOTECHNOLOGY | 1996年 / 6卷 / 02期

关键词：

capillary electrophoresis; affinity; DNA; mutation detection; association constant;

D O I：

10.1007/BF02740769

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Capillary affinity gel electrophoresis is a new technique for the recognition of the specific DNA base and/or sequence. This technology is also applicable to the characterization of binding properties of DNA-based drugs, chiral separation, and the selection separation of antibody mimetics using imprinted polymers. This article reviews the present state of studies on the capillary affinity gel electrophoresis, including the principle, theory, methods, and applications of this technology. The great potential of capillary affinity gel electrophoresis for the detection of the mutation onDNA is illustrated.

引用

页码：143 / 153

页数：11

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