Carotid atherosclerosis in women with polycystic ovary syndrome: Initial results from a case-control study

Objective: Our our purpose was to determine whether women with polycystic ovary syndrome have greater subclinical atherosclerosis as measured by carotid artery ultrasonography. Study Design: Sixteen premenopausal women less than 40 years old with a history of clinical polycystic ovary syndrome and a current total testosterone concentration less than or equal to 2.0nmol/L and 16 age-matched (plus or minus 5 years) cycling women underwent carotid scanning. Intima-media thickness and plaque were compared between cases and controls, as were risk factors for atherosclerosis including body mass index and fasting insulin and lipid levels. Statistical analysis included t tests, Fisher's exact test, and multiple linear regression. Results: Mean plus or minus SE intima-media thickness was found to be significantly greater for cases with polycystic ovary syndrome (0.680 plus or minus 0.019 mm) than for controls (0.630 plus or minus 0.012 mm) (t=2.31, p=0.035). Five cases (31.3%) and two controls (12.5%) had ultrasonographic evidence of plaque (not significant). Univariate regressions of intima-media thickness yielded significant coefficients for insulin, total cholesterol, low-density lipoprotein cholesterol and body mass index. When either total cholesterol or low-density lipoprotein were included in the model simultaneously with polycystic ovary syndrome, each retained significance. This was not true for insulin and body mass index, however, suggesting that these factors covaried with polycystic ovary syndrome in a dimension affecting intima-media thickness. Conclusions: In spite of a major limitation of small sample size, these data suggest that women with polycystic ovary syndrome have an increased risk of subclinical atherosclerosis in their 40s.