Experience-dependent modification of mechanisms of long-term depression

被引：40

作者：

Jo, J

Ball, SM

Seok, H

Oh, SB

Massey, PV

Molnar, E

Bashir, ZI

Cho, K

机构：

[1] Univ Sheffield, Sch Med & Biomed Sci, Sheffield S10 2TN, S Yorkshire, England

[2] Univ Bristol, Dept Anat, MRC, Ctr Synapt Plastic, Bristol BS8 1TD, Avon, England

[3] Seoul Natl Univ, Mol & Cellular Neurosci Program, Dept Physiol, Coll Dent, Seoul 110749, South Korea

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nn1637

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mechanisms of long-term potentiation and depression ( LTP and LTD) change considerably during development, but the importance of these changes and the factors that control them is not clear. We found that visual experience triggered a switch in mechanisms of LTD in rat perirhinal cortex, an area critical for visual recognition memory. Thus, changes in synaptic plasticity mechanisms were correlated with the changing physiological demands on the CNS.

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收藏

页码：170 / 172

页数：3

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