Comparison of multiple vaccine vectors in a single heterologous prime-boost trial

被引：41

作者：

Barefoot, Brice ^{[1
]}

Thornburg, Natalie J. ^{[2
]}

Barouch, Daniel H. ^{[3
]}

Yu, Jae-sung ^{[1
]}

Sample, Christopher ^{[1
]}

Johnston, Robert E. ^{[2
]}

Liao, Hua Xin ^{[1
]}

Kepler, Thomas B. ^{[4
]}

Haynes, Barton F. ^{[1
]}

Ramsburg, Elizabeth ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Sch Med, Duke Human Vaccine Inst, Durham, NC 27710 USA

[2] Univ N Carolina, Carolina Vaccine Inst, Chapel Hill, NC 27599 USA

[3] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Viral Pathogenesis, Boston, MA 02115 USA

[4] Duke Univ, Ctr Computat Immunol, Dept Biostat & Bioinformat, Durham, NC 27710 USA

来源：

VACCINE | 2008年 / 26卷 / 48期

基金：

美国国家卫生研究院;

关键词：

Vaccine; Viral vector; Poxvirus;

D O I：

10.1016/j.vaccine.2008.09.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The prevention of infectious disease via prophylactic immunization is a mainstay of global public health efforts. Vaccine design Would be facilitated by a better understanding of the type and durability of immune responses generated by different vaccine vectors. We report here the results of a comparative immunogenicity trial of six different vaccine vectors expressing the same insert antigen, cowpox virus 135 (CPXV-B5). Of those vectors tested, recombinant adenovirus (rAd5) was the most immunogenic, inducing the highest titer anti-135 antibodies and conferring protection from sublethal vaccinia virus challenge in mice after a single immunization. We tested select heterologous prime-boost combinations and identified recombinant vesicular stomatitis virus (rVSV) and recombinant Venezuelan equine encephalitis virus replicons (VRP) as the most synergistic regimen. Comparative data Such as those presented here are critical to efforts to generate protective vaccines for emerging infectious diseases as well as for biothreat agents. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6108 / 6118

页数：11

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