Platelet-derived serotonin mediates liver regeneration

被引：627

作者：

Lesurtel, M

Graf, R

Aleil, B

Walther, DJ

Tian, YH

Jochum, W

Gachet, C

Bader, M

Clavien, PA ^{[1
]}

机构：

[1] Univ Zurich Hosp, Dept Visceral & Transplantat Surg, Zurich, Switzerland

[2] Univ Zurich Hosp, Dept Pathol, Zurich, Switzerland

[3] INSERM, U311, Estab Francais Sang Alsace, Strasbourg, France

[4] Max Planck Inst Mol Genet, Berlin, Germany

[5] Max Delbruck Ctr Mol Med, Berlin, Germany

来源：

SCIENCE | 2006年 / 312卷 / 5770期

关键词：

D O I：

10.1126/science.1123842

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The liver can regenerate its volume after major tissue loss. In a mouse model of liver regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate cellular proliferation in the liver. Platelets are major carriers of serotonin in the blood. In thrombocytopenic mice, a serotonin agonist reconstituted liver proliferation. The expression of 5-HT2A and 2B subtype serotonin receptors in the liver increased after hepatectomy. Antagonists of 5-HT2A and 2B receptors inhibited liver regeneration. Liver regeneration was also blunted in mice lacking tryptophan hydroxylase 1, which is the rate-limiting enzyme for the synthesis of peripheral serotonin. This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration.

引用

页码：104 / 107

页数：4

共 41 条

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