Origins and implications of pluripotent stem cell variability and heterogeneity

被引：242

作者：

Cahan, Patrick

Daley, George Q. ^{[1
]}

机构：

[1] Childrens Hosp, Howard Hughes Med Inst, Stem Cell Transplantat Program, Div Pediat Hematol & Oncol,Manton Ctr Orphan Dis, Boston, MA 02115 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2013年 / 14卷 / 06期

基金：

美国国家卫生研究院;

关键词：

TRANSCRIPTIONAL REGULATORY CIRCUITRY; GENE-EXPRESSION SIGNATURES; HUMAN SOMATIC-CELLS; SELF-RENEWAL; COPY NUMBER; HUMAN ES; DIFFERENTIATION PROPENSITY; NEURAL DIFFERENTIATION; MOLECULAR SIGNATURE; CHROMATIN-STRUCTURE;

D O I：

10.1038/nrm3584

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Pluripotent stem cells constitute a platform to model disease and developmental processes and can potentially be used in regenerative medicine. However, not all pluripotent cell lines are equal in their capacity to differentiate into desired cell types in vitro. Genetic and epigenetic variations contribute to functional variability between cell lines and heterogeneity within clones. These genetic and epigenetic variations could 'lock' the pluripotency network resulting in residual pluripotent cells or alter the signalling response of developmental pathways leading to lineage bias. The molecular contributors to functional variability and heterogeneity in both embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are only beginning to emerge, yet they are crucial to the future of the stem cell field.

引用

页码：357 / 368

页数：12

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