学术探索
学术期刊
新闻热点
数据分析
智能评审

Plasmid DNA expression systems for the purpose of immunization

被引：64
作者：
Davis, HL
机构：
[1] Ottawa Civic Hospital, Loeb Research Institute, Ottawa, Ont. K1Y 4E9
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 1997年 / 8卷 / 05期
关键词：
D O I：
10.1016/S0958-1669(97)80041-9
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
DNA vaccines induce immune responses against antigens synthesized in vivo after direct introduction of the DNA's encoding sequences. This unique approach to immunization may overcome deficits of traditional antigen-based approaches and provide safe and effective prophylactic and therapeutic vaccines. DNA vaccines are also useful as a research tool, such as for production of monoclonal antibodies. Efforts are now focusing on understanding the mechanism of antigen presentation and the adjuvant effect of immunostimulatory CpG motifs in the vectors to aid optimization of DNA vaccines.
引用
收藏
页码：635 / 640
页数：6
相关论文
共 61 条
  • [1] Anderson ED, 1996, MOL MAR BIOL BIOTECH, V5, P114
  • [2] Ballas ZK, 1996, J IMMUNOL, V157, P1840
  • [3] PROTECTION AGAINST MYCOPLASMA-INFECTION USING EXPRESSION-LIBRARY IMMUNIZATION
    BARRY, MA
    LAI, WC
    JOHNSTON, SA
    [J]. NATURE, 1995, 377 (6550) : 632 - 635
  • [4] BARRY MA, 1997, IN PRESS VACCINE, V15
  • [5] Bot A., 1997, FRONT BIOSCI, V2, P173
  • [6] Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination
    Boyer, JD
    Ugen, KE
    Wang, B
    Agadjanyan, M
    Gilbert, L
    Bagarazzi, ML
    Chattergoon, M
    Frost, P
    Javadian, A
    Williams, WV
    Refaeli, Y
    Ciccarelli, RB
    McCallus, D
    Coney, L
    Weiner, DB
    [J]. NATURE MEDICINE, 1997, 3 (05) : 526 - 532
  • [7] Induction of antigen-specific tumor immunity by genetic and cellular vaccines against MAGE: Enhanced tumor protection by coexpression of granulocyte-macrophage colony-stimulating factor and B7-1
    Bueler, H
    Mulligan, RC
    [J]. MOLECULAR MEDICINE, 1996, 2 (05) : 545 - 555
  • [8] Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2
    Chow, YH
    Huang, WL
    Chi, WK
    Chu, YD
    Tao, MH
    [J]. JOURNAL OF VIROLOGY, 1997, 71 (01) : 169 - 178
  • [9] Ciernik IF, 1996, J IMMUNOL, V156, P2369
  • [10] DNA-based immunization by in vivo transfection of dendritic cells
    Condon, C
    Watkins, SC
    Celluzzi, CM
    Thompson, K
    Falo, LD
    [J]. NATURE MEDICINE, 1996, 2 (10) : 1122 - 1128
1234567