Regeneration of fat cells from myofibroblasts during wound healing

被引：583

作者：

Plikus, Maksim V. ^{[1
,4
,5
,6
]}

Guerrero-Juarez, Christian F. ^{[1
,12
,13
,18
]}

Ito, Mayumi ^{[7
,8
,11
,16
,19
]}

Li, Yun Rose ^{[2
,4
,14
]}

Dedhia, Priya H. ^{[1
,6
,15
,19
]}

Zheng, Ying ^{[5
,7
,18
]}

Shao, Mengle ^{[2
,3
,4
,6
,13
,19
]}

Gay, Denise L. ^{[5
,11
,15
,16
,17
]}

Ramos, Raul ^{[10
,14
,17
]}

Hsi, Tsai-Ching ^{[16
]}

Oh, Ji Won ^{[15
]}

Wang, Xiaojie ^{[6
,7
,10
,11
,13
]}

Ramirez, Amanda ^{[3
,14
]}

Konopelski, Sara E. ^{[4
,7
,11
,15
]}

Elzein, Arijh ^{[1
,7
,12
,15
,19
]}

Wang, Anne ^{[3
,6
,8
,11
]}

Supapannachart, Rarinthip June ^{[1
,4
,6
,13
,19
]}

Lee, Hye-Lim ^{[2
,3
,5
,11
]}

Lim, Chae Ho ^{[13
]}

Nace, Arben ^{[11
]}

Guo, Amy ^{[2
,3
,13
,16
]}

Treffeisen, Elsa ^{[1
,5
]}

Andl, Thomas ^{[4
,5
,6
,7
]}

Ramirez, Ricardo N. ^{[5
,8
]}

Murad, Rabi ^{[7
]}

Offermanns, Stefan ^{[1
,2
,17
]}

Metzger, Daniel ^{[9
,13
]}

Chambon, Pierre ^{[4
,17
]}

Widgerow, Alan D.

Tuan, Tai-Lan ^{[3
,4
,13
]}

Mortazavi, Ali ^{[9
]}

Gupta, Rana K. ^{[1
]}

Hamilton, Bruce A. ^{[4
,7
,17
]}

Millar, Sarah E.

Seale, Patrick ^{[1
,3
,4
,13
]}

Pear, Warren S. ^{[2
]}

Lazar, Mitchell A. ^{[4
,7
]}

Cotsarelis, George

机构：

[1] Univ Penn, Perelman Sch Med, Dept Dermatol, Kligman Labs, Philadelphia, PA 19104 USA

[2] Univ Calif Irvine Irvine, Dept Dev & Cell Biol, Sue & Bill Gross Stem Cell Res Ctr, Ctr Complex Biol Syst, Irvine, CA 92697 USA

[3] NYU, Ronald Perelman Dept Dermatol, Dept Cell Biol, Sch Med, New York, NY 10016 USA

[4] Univ Penn, Ronald O Perelman Dept, Philadelphia, PA 19104 USA

[5] Univ Penn, Abramson Family Canc Res Inst, Inst Med & Engn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[6] Univ Texas Southwestern Med Ctr, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA

[7] Inst Radiobiol Cellulaire & Mol, INSERM U967, Commissariat Lanergie Atom & Nergies Alternat, F-92265 Fontenay Aux Roses, France

[8] Kyungpook Natl Univ, Sch Med, Dept Anat, Daegu, South Korea

[9] Univ Cent Florida, Burnett Sch Biomed Sci, Orlando, FL 32811 USA

[10] Max Planck Inst Heart & Lung Res, Dept Pharmacol, D-61231 Bad Nauheim, Germany

[11] Univ Strasbourg, CNRS, Inst Genet & Biol Mol & Cellulaire, INSERM, F-67404 Illkirch Graffenstaden, France

[12] Univ Strasbourg, Inst Etudes Avancees, Coll France, Inst Genet & Biol Mol & Ceullaire, F-67404 Illkirch Graffenstaden, France

[13] Univ Calif Irvine, Dept Plast Surg, Ctr Tissue Engn, Irvine, CA 92868 USA

[14] Saban Res Inst Childrens Hosp Angeles & Dept Surg, Univ So Calif, Keck Sch Med, Los Angeles, CA 90027 USA

[15] Univ Calif San Diego, Dept Med, San Diego, CA 92093 USA

[16] Univ Calif San Diego, Dept Mol Med Moores Canc Ctr, San Diego, CA 92093 USA

[17] Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

[18] Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

[19] Univ Penn, Perelman Sch Med, Dept Med, Div Endocrinol, Philadelphia, PA 19104 USA

来源：

SCIENCE | 2017年 / 355卷 / 6326期

基金：

新加坡国家研究基金会; 加拿大健康研究院;

关键词：

SKIN; DIFFERENTIATION; NEOGENESIS;

D O I：

10.1126/science.aai8792

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed in mammals. We discovered in the mouse that during wound healing, adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and nonadipogenic. Myofibroblast reprogramming required neogenic hair follicles, which triggered bone morphogenetic protein (BMP) signaling and then activation of adipocyte transcription factors expressed during development. Overexpression of the BMP antagonist Noggin in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte formation. Adipocytes formed from human keloid fibroblasts either when treated with BMP or when placed with human hair follicles in vitro. Thus, we identify the myofibroblast as a plastic cell type that may be manipulated to treat scars in humans.

引用

页码：748 / +

页数：5

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