Biochemical and molecular mechanisms of drug resistance in parasites

被引：57

作者：

Ouellette, M

机构：

[1] CHU Laval, Ctr Rech Infectiol, Quebec City, PQ G1V 4G2, Canada

[2] Univ Laval, Fac Med, Dept Microbiol, Quebec City, PQ G1K 7P4, Canada

来源：

TROPICAL MEDICINE & INTERNATIONAL HEALTH | 2001年 / 6卷 / 11期

关键词：

drug resistance; chloroquine; antimonials; arsenicals;

D O I：

10.1046/j.1365-3156.2001.00777.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Drug resistance is complicating the treatment of parasitic diseases. We review here the basic mechanisms of parasite resistance in malaria, sleeping sickness, leishmaniasis and common helminthiases. Parasites resort to multiple biochemical means to achieve resistance and we have begun to isolate and characterize the genes/proteins implicated in resistance. Understanding drug resistance is essential for the control of parasitic diseases.

引用

页码：874 / 882

页数：9

共 83 条

[1]

ARREBOLA R, 1994, J BIOL CHEM, V269, P10590

[2] SELECTION FOR HIGH-LEVEL CHLOROQUINE RESISTANCE RESULTS IN DEAMPLIFICATION OF THE PFMDR1 GENE AND INCREASED SENSITIVITY TO MEFLOQUINE IN PLASMODIUM-FALCIPARUM [J].