Treatment outcome of CRLF2-rearranged childhood acute lymphoblastic leukaemia: a comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups

被引：36

作者：

Attarbaschi, Andishe ^{[1
]}

Morak, Maria ^{[2
]}

Cario, Gunnar ^{[3
]}

Cazzaniga, Giovanni ^{[4
]}

Ensor, Hannah M. ^{[5
]}

te Kronnie, Truus ^{[6
]}

Bradtke, Jutta ^{[7
]}

Mann, Georg ^{[1
]}

Vendramini, Elena ^{[6
]}

Palmi, Chiara ^{[4
]}

Schwab, Claire ^{[5
]}

Russell, Lisa J. ^{[5
]}

Schrappe, Martin ^{[3
]}

Conter, Valentino

Mitchell, Christopher D. ^{[8
]}

Strehl, Sabine ^{[2
]}

Zimmermann, Martin ^{[9
]}

Poetschger, Ulrike ^{[2
]}

Harrison, Christine J. ^{[5
]}

Stanulla, Martin ^{[3
]}

Panzer-Gruemayer, Renate ^{[1
,2
]}

Haas, Oskar A. ^{[1
]}

Moorman, Anthony V. ^{[5
]}

机构：

[1] Med Univ Vienna, St Anna Childrens Hosp, Dept Paediat, A-1090 Vienna, Austria

[2] Childrens Canc Res Inst St Anna Kinderkrebsforsch, Vienna, Austria

[3] Univ Schleswig Holstein, Kiel, Germany

[4] Univ Milano Bicocca, Ctr Ric M Tettamanti, Monza, Italy

[5] Newcastle Univ, No Inst Canc Res, Leukaemia Res Cytogenet Grp, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[6] Univ Padua, SSD Ematol Clin & Sperimentale, Dept Paediat Salus Pueri, Padua, Italy

[7] Univ Giessen, Giessen, Germany

[8] John Radcliffe Hosp, Oxford OX3 9DU, England

[9] Hannover Med Sch, D-3000 Hannover, Germany

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2012年 / 158卷 / 06期

关键词：

acute leukaemia; childhood leukaemia; genetics; B-PROGENITOR; CRLF2; REARRANGEMENT; CHILDREN; IKZF1; JAK;

D O I：

10.1111/j.1365-2141.2012.09221.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prognostic relevance of CRLF2 -rearrangements in childhood acute B-cell precursor lymphoblastic leukaemia (ALL), was assessed by a comparative analysis of 114 non-Down-syndrome patients (99 P2RY8-CRLF2+ , 15 IGH@-CRLF2+ ), 76 from the AIEOP-BFM ALL 2000 and 38 from the MRC ALL97 trials. The 6-year cumulative relapse incidence of P2RY8-CRLF2+ patients treated on the two trials was not statistically different: 0.37 +/- 0.06 vs. 0.25 +/- 0.08 (P = 0.194). In contrast, 0/9 IGH@-CRLF2+ AIEOP-BFM, but 5/6 ALL97 patients relapsed. Conclusively, P2RY8-CRLF2+ patients had an intermediate protocol-independent outcome while the different prognosis of IGH@-CRLF2+ patients could be related to the different structures of the applied treatment protocols.

引用

页码：772 / 777

页数：6

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