Cell-free Screening for NOX Inhibitors

被引：4

作者：

Bedard, Karen ^{[2
]}

Jaquet, Vincent ^{[1
]}

机构：

[1] Geneva Univ Hosp Ctr Med Univ, Geneva Med Fac, Dept Pathol & Immunol, CH-1211 Geneva 4, Switzerland

[2] Dalhousie Univ, Dept Pathol, Halifax, NS B3H 4R2, Canada

来源：

CHEMISTRY & BIOLOGY | 2012年 / 19卷 / 06期

关键词：

NADPH OXIDASE; EBSELEN; ACTIVATION; COMPOUND;

D O I：

10.1016/j.chembiol.2012.06.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NOX enzymes are major ROS generators in pathological states and represent a promising pharmacological target. In this issue of Chemistry & Biology, Smith and colleagues developed an original and elegant cell-free assay to identify specific Nox2 inhibitors in a high throughput manner.

引用

收藏

页码：664 / 665

页数：2

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