Impact of Beta-Amyloid-Specific Florbetaben PET Imaging on Confidence in Early Diagnosis of Alzheimer's Disease

被引:58
作者
Schipke, C. G. [1 ]
Peters, O. [1 ]
Heuser, I. [1 ]
Grimmer, T. [4 ]
Sabbagh, M. N. [2 ]
Sabri, O. [5 ]
Hock, C. [6 ]
Kunz, M. [3 ]
Kuhlmann, J. [3 ]
Reininger, C. [3 ]
Blankenburg, M. [3 ]
机构
[1] Charite Campus Benjamin Franklin, Dept Psychiat, DE-14050 Berlin, Germany
[2] Banner Sun Hlth Res Inst, Sun City, AZ USA
[3] Bayer HealthCare Pharmaceut, Berlin, Germany
[4] Tech Univ Munich, Klinikum Rechts Isar, Dept Psychiat & Psychotherapy, D-8000 Munich, Germany
[5] Univ Hosp Leipzig, Dept Nucl Med, Leipzig, Germany
[6] Psychiat Univ Hosp, Hosp Psychogeriatr Med, Zurich, Switzerland
关键词
Alzheimer's disease; Beta-amyloid plaques; Florbetaben amyloid imaging; PITTSBURGH COMPOUND-B; CEREBROSPINAL-FLUID; BIOMARKERS; PLASMA; CSF;
D O I
10.1159/000339367
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: Early diagnosis of Alzheimer's disease (AD) may be corroborated by imaging of beta-amyloid plaques using positron emission tomography (PET). Here, we performed an add-on questionnaire study to evaluate the relevance of florbetaben imaging (BAY 94-9172) in diagnosis and consecutive management of probable AD patients. Methods: AD patients with a clinical diagnosis in accordance with the NINCDS-ADRDA criteria or controls were imaged using florbetaben. Referring physicians were asked on a voluntary basis about their confidence in initial diagnosis, significance of PET imaging results, and their anticipated consequences for future patient care. Results: 121 questionnaires for probable AD patients and 80 questionnaires for controls were evaluated. In 18% of patients who had initially received the diagnosis of probable AD, PET scans were rated negative, whereas in controls 18% of scans were positive. An increase in confidence in the initial diagnosis was frequently reported (80%). Imaging results had a significant impact on the intended patient care, as judged by the referring physicians; this was most prominent in those patients with a contradicting scan and/or a low confidence in the initial diagnosis. Conclusion: Florbetaben amyloid imaging increases the overall confidence in diagnosis of AD and may frequently influence clinical decisions and patient management. Copyright (c) 2012 S. Karger AG, Basel
引用
收藏
页码:416 / 422
页数:7
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