Neurogliaform cells dynamically regulate somatosensory integration via synapse-specific modulation

被引：51

作者：

Chittajallu, Ramesh ^{[1
]}

Pelkey, Kenneth A. ^{[1
]}

McBain, Chris J. ^{[1
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Dev Neurobiol, NIH, Bethesda, MD USA

来源：

NATURE NEUROSCIENCE | 2013年 / 16卷 / 01期

关键词：

INHIBITION; RECEPTOR; CORTEX; ACTIVATION; NEOCORTEX; RESPONSES; AMYGDALA; NEURONS; DRIVEN;

D O I：

10.1038/nn.3284

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Despite the prevailing idea that neurogliaform cells produce a spatially unrestricted widespread inhibition, we demonstrate here that their activity attenuates thalamic-evoked feed-forward inhibition in layer IV barrel cortex but has no effect on feed-forward excitation. The result of this circuit selectivity is a dynamic regulation in the temporal window for integration of excitatory thalamic input, thus revealing a new role for neurogliaform cells in shaping sensory processing.

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页码：13 / U167

页数：4

相关论文

共 18 条

[1] THALAMOCORTICAL RESPONSES OF MOUSE SOMATOSENSORY (BARREL) CORTEX INVITRO [J].

AGMON, A ;

CONNORS, BW .

NEUROSCIENCE, 1991, 41 (2-3) :365-379

[2] Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons [J].

Belachew, S ;

Chittajallu, R ;

Aguirre, AA ;

Yuan, XQ ;

Kirby, M ;

Anderson, S ;

Gallo, V .

JOURNAL OF CELL BIOLOGY, 2003, 161 (01) :169-186

[3] Cortex is driven by weak but synchronously active thalamocortical synapses [J].

Bruno, Randy M. ;

Sakmann, Bert .

SCIENCE, 2006, 312 (5780) :1622-1627

[4] Emergence of cortical inhibition by coordinated sensory-driven plasticity at distinct synaptic loci [J].

Chittajallu, Ramesh ;

Isaac, John T. R. .

NATURE NEUROSCIENCE, 2010, 13 (10) :1240-1248

[5] Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex [J].

Cruikshank, Scott J. ;

Lewis, Timothy J. ;

Connors, Barry W. .

NATURE NEUROSCIENCE, 2007, 10 (04) :462-468

[6] The Logic of Inhibitory Connectivity in the Neocortex [J].

Fino, Elodie ;

Packer, Adam M. ;

Yuste, Rafael .

NEUROSCIENTIST, 2013, 19 (03) :228-237

[7] Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition [J].

Gabernet, L ;

Jadhav, SP ;

Feldman, DE ;

Carandini, M ;

Scanziani, M .

NEURON, 2005, 48 (02) :315-327

[8]

Gonzalez-Burgos G, 2010, ADV PHARMACOL, V58, P175, DOI 10.1016/S1054-3589(10)58008-6

[9] Slow GABA Transient and Receptor Desensitization Shape Synaptic Responses Evoked by Hippocampal Neurogliaform Cells [J].

Karayannis, Theofanis ;

Elfant, David ;

Huerta-Ocampo, Icnelia ;

Teki, Sundeep ;

Scott, Ricardo S. ;

Rusakov, Dmitri A. ;

Jones, Mathew V. ;

Capogna, Marco .

JOURNAL OF NEUROSCIENCE, 2010, 30 (29) :9898-9909

[10] The Largest Group of Superficial Neocortical GABAergic Interneurons Expresses Ionotropic Serotonin Receptors [J].

Lee, SooHyun ;

Hjerling-Leffler, Jens ;

Zagha, Edward ;

Fishell, Gord ;

Rudy, Bernardo .

JOURNAL OF NEUROSCIENCE, 2010, 30 (50) :16796-16808