Troglitazone suppresses cell growth of myeloid leukemia cell lines by induction of p21WAF1/CIP1 cyclin-dependent kinase inhibitor

被引：79

作者：

Sugimura, A

Kiriyama, Y

Nochi, H

Tsuchiya, H

Tamoto, K

Sakurada, Y

Ui, M

Tokumitsu, Y ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Dept Physiol Chem, Sapporo, Hokkaido 0600812, Japan

[2] Hlth Sci Univ Hokkaido, Fac Pharmaceut Sci, Dept Immunol, Ishikari, Hokkaido 0610212, Japan

[3] Tokyo Metropolitan Inst Med Sci, Tokyo 1130021, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 261卷 / 03期

关键词：

D O I：

10.1006/bbrc.1999.1049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a human eosinophilic leukemia cell line, EoL-1, cell proliferation was suppressed by a-day treatment with troglitazone, EoL-1 cells treated with troglitazone were arrested and maintained in the G0/G1 phase in the cell cycle. This suppression correlated with the up-regulation of mRNA for p21WAF1/CIP1 cyclin-dependent kinase (Cdk) inhibitor. The inhibitory effects of troglitazone on cell proliferation and expression of p21 mRNA were observed in a human myelomonocytic cell line, U937, and a human myelomonoblastic cell line, KPB-M15. In addition, in EoL-1 cells, p21 protein was induced by troglitazone treatment and the induction was inhibited by protein synthesis inhibitor, cycloheximide. These data suggest that troglitazone inhibits cell proliferation in myeloid leukemia cell lines at least in part by induction of p21 Cdk inhibitor. (C) 1999 Academic Press.

引用

页码：833 / 837

页数：5

共 23 条

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