Recommendations for Preclinical Research in Hemorrhagic Transformation

被引：32

作者：

Fagan, Susan C. ^{[1
,2
,3
]}

Lapchak, Paul A. ^{[5
]}

Liebeskind, David S. ^{[6
]}

Ishrat, Tauheed ^{[1
,2
]}

Ergul, Adviye ^{[1
,2
,4
]}

机构：

[1] Univ Georgia, Coll Pharm, Program Clin & Expt Therapeut, Augusta, GA 30912 USA

[2] Charlie Norwood VA Med Ctr, Augusta, GA USA

[3] Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USA

[4] Med Coll Georgia, Dept Physiol, Augusta, GA 30912 USA

[5] Cedars Sinai Med Ctr, Dept Neurol, Los Angeles, CA 90048 USA

[6] Univ Calif Los Angeles, Stroke Ctr, Los Angeles, CA USA

来源：

TRANSLATIONAL STROKE RESEARCH | 2013年 / 4卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Hemorrhagic transformation; Ischemic stroke; Tissue plasminogen activator; Animal models; Hemorrhagic infarction; TISSUE-PLASMINOGEN ACTIVATOR; EXPERIMENTAL CEREBRAL-ISCHEMIA; EMBOLIC STROKE MODEL; VASCULAR PROTECTION; INTRACEREBRAL HEMORRHAGE; BRAIN HEMORRHAGE; RAT MODEL; HYPERTENSION; CANDESARTAN; MINOCYCLINE;

D O I：

10.1007/s12975-012-0222-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Hemorrhagic transformation (HT) is an important complication of ischemic stroke and is responsible for most of the mortality associated with acute reperfusion therapy. Although many important publications address the preclinical models of ischemic stroke, there are no current recommendations on the conduct of research aimed at understanding the mechanisms and consequences of HT. The purpose of this review is to present the various models used in HT research, the clinical correlates, and the experimental variables known to influence the quantitation of HT in preclinical investigation. Lastly, recommendations for the conduct of preclinical research in HT are provided.

引用

页码：322 / 327

页数：6

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