Successful Treatment of Disseminated Acanthamoeba sp Infection with Miltefosine

被引：81

作者：

Aichelburg, Alexander C. ^{[1
]}

Walochnik, Julia ^{[2
]}

Assadian, Ojan ^{[2
]}

Prosch, Helmut

Steuer, Andrea

Perneczky, Gedeon ^{[3
]}

Visvesvara, Govinda S. ^{[4
]}

Aspoeck, Horst ^{[2
]}

Vetter, Norbert

机构：

[1] Otto Wagner Hosp, Pulmonol Ctr, SMZ Baumgartner Hoehe, A-1140 Vienna, Austria

[2] Med Univ Vienna, Vienna, Austria

[3] Krankenanstalt Rudolfstiftung Wien, Vienna, Austria

[4] Ctr Dis Control & Prevent, Atlanta, GA USA

来源：

EMERGING INFECTIOUS DISEASES | 2008年 / 14卷 / 11期

关键词：

D O I：

10.3201/eid1411.070854

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report on an HIV-negative but immunocompromised patient with disseminated acanthamoebiasis, granulomatous, amoebic encephalitis, and underlying miliary tuberculosis and tuberculous meningitis. The patient responded favorably to treatment with miltefosine, an alkylphosphocholine. The patient remained well with no signs of infection 2 years after treatment cessation.

引用

页码：1743 / 1746

页数：4

共 15 条

[1] Fatal disseminated Acanthamoeba lenticulata infection in a heart transplant patient [J].

Barete, Stephane ;

Combes, Alain ;

de Jonckheere, Johan F. ;

Datry, Annick ;

Varnous, Shaida ;

Martinez, Valerie ;

Ptacek, Sara Garcia ;

Caumes, Eric ;

Capron, Frederique ;

Frances, Camille ;

Gibert, Claude ;

Chosidow, Olivier .

EMERGING INFECTIOUS DISEASES, 2007, 13 (05) :736-738

[2] Inability to make a premortem diagnosis of Acanthamoeba species infection in a patient with fatal granulomatous Amebic encephalitis [J].

Bloch, KC ;

Schuster, FL .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (06) :3003-3006

[3] Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis [J].

Jha, TK ;

Sundar, S ;

Thakur, CP ;

Bachmann, P ;

Karbwang, J ;

Fischer, C ;

Voss, A ;

Berman, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (24) :1795-1800

[4] ISOLATION OF ACANTHAMOEBA-CULBERTSONI FROM A PATIENT WITH MENINGITIS [J].

LALITHA, MK ;

ANANDI, V ;

SRIVASTAVA, A ;

THOMAS, K ;

CHERIAN, AM ;

CHANDI, SM .

JOURNAL OF CLINICAL MICROBIOLOGY, 1985, 21 (04) :666-667

[5] Acanthamoeba spp. as agents of disease in humans [J].

Marciano-Cabral, F ;

Cabral, G .

CLINICAL MICROBIOLOGY REVIEWS, 2003, 16 (02) :273-+

[6] Granulomatous amebic encephalitis in a patient with AIDS:: Isolation of Acanthamoeba sp group II from brain tissue and successful treatment with sulfadiazine and fluconazole [J].

Martinez, MS ;

Gonzalez-Mediero, G ;

Santiago, P ;

de Lope, AR ;

Diz, J ;

Conde, C ;

Visvesvara, GS .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (10) :3892-3895

[7] GRANULOMATOUS BRAIN-TUMOR CAUSED BY ACANTHAMOEBA - CASE-REPORT [J].

OFORIKWAKYE, SK ;

SIDEBOTTOM, DG ;

HERBERT, J ;

FISCHER, EG ;

VISVESVARA, GS .

JOURNAL OF NEUROSURGERY, 1986, 64 (03) :505-509

[8] Early diagnosis of Acanthamoeba infection during routine cytological examination of cerebrospinal fluid [J].

Petry, F ;

Torzewski, M ;

Bohl, J ;

Wilhelm-Schwenkmezger, T ;

Scheid, P ;

Walochnik, J ;

Michel, R ;

Zoller, L ;

Werhahn, KJ ;

Bhakdi, S ;

Lackner, KJ .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (05) :1903-1904

[9] Use of subgenic 18S ribosomal DNA PCR and sequencing for genus and genotype identification of acanthamoebae from humans with keratitis and from sewage sludge [J].

Schroeder, JM ;

Booton, GC ;

Hay, J ;

Niszl, IA ;

Seal, DV ;

Markus, MB ;

Fuerst, PA ;

Byers, TJ .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (05) :1903-1911

[10] Opportunistic amoebae: challenges in prophylaxis and treatment [J].

Schuster, FL ;

Visvesvara, GS .

DRUG RESISTANCE UPDATES, 2004, 7 (01) :41-51

← 1 2 →