Distribution and metabolic syndrome correlates of plasma C-reactive protein in biracial (black-white) younger adults: the Bogalusa Heart Study

被引：49

作者：

Patel, Dharmendrakumar A. ^{[1
]}

Srinivasan, Sathanur R. ^{[1
]}

Xu, Ji-Hua ^{[1
]}

Li, Shengxu ^{[1
]}

Chen, Wei ^{[1
]}

Berenson, Gerald S. ^{[1
]}

机构：

[1] Tulane Univ, Ctr Hlth Sci, Tulane Ctr Cardiovasc Hlth, New Orleans, LA 70112 USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2006年 / 55卷 / 06期

关键词：

D O I：

10.1016/j.metabol.2005.07.015

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The association between plasma C-reactive protein (CRP), a marker of systemic inflammation, and the metabolic syndrome is well recognized. However, information is scant regarding the component of metabolic syndrome that is critical in modulating CRP levels in younger adults. This aspect was examined in a biracial (black-white) community-based sample of 1083 younger adults (mean age, 36.1 years; 71% white, 45% male) enrolled in the Bogalusa Heart Study. Plasma CRP along with metabolic syndrome variables were measured. CRP levels showed a significant race (black > white, P = .01) and sex (female > male, P = .0001) differences, and related to measures of obesity (body mass index [BMI], waist circumference, an sagittal diameter), blood pressure (systolic, diastolic, and mean arterial blood pressure), lipoproteins (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, total cholesterol-high-density lipoprotein cholesterol ratio), glucose homeostasis (insulin, glucose, homeostasis model assessment of insulin resistance), and uric acid, after adjusting for age, race, sex, and cigarette smoking. Furthermore, CRP levels increased with increasing number of metabolic syndrome risk factors, as defined by the National Cholesterol Education Program Adult Treatment Panel III, regardless of race and sex (P for trend < .0001). In multivariate analysis, using 3 separate models for different obesity measures, obesity was the major contributor to the explained variance in each model with BMI, waist, and sagittal diameter contributing 17.0%, 13.4%, and 17.1% of the variance, respectively. In contrast, homeostasis model assessment of insulin resistance contributed 1.2%, 0.3%, and 0% to the explained variance in the models with BMI, waist, and sagittal diameter, respectively. In conclusions, CRP levels differ among race and sex groups and correlate to metabolic syndrome variables in younger adults. In addition, these findings strongly suggest that although obesity and insulin resistance are the main underlying features of the metabolic syndrome, the former appears to be the major mediator of CRP levels, which has important health implications. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：699 / 705

页数：7

共 56 条

[1]

Ross R., Atherosclerosis: an inflammatory disease, N Engl J Med, 340, pp. 115-126, (1999)

[2]

Ridker P.M., Buring J.E., Shih J., Matias M., Hennekens C.H., Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women, Circulation, 98, pp. 731-733, (1998)

[3]

Tracy R.P., Lemaitre R.N., Psaty B.M., Ives D.G., Evans R.W., Cushman M., Et al., Relationship of C-reactive protein to risk of cardiovascular disease in the elderly: results from the Cardiovascular Health Study and the Rural Health Promotion Project, Arterioscler Thromb Vasc Biol, 17, pp. 1121-1127, (1997)

[4]

Kuller L.H., Tracy R.P., Shaten J., Meilahn E.N., Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study: Multiple Risk Factor Intervention Trial, Am J Epidemiol, 144, pp. 537-547, (1996)

[5]

Koenig W., Sund M., Frohlich M., Fischer H.G., Lowel H., Doring A., Et al., C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992, Circulation, 99, pp. 237-242, (1999)

[6]

Festa A., D'Agostino Jr. R., Howard G., Mykkanen L., Tracy R.P., Haffner S.M., Chronic sub-clinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS), Circulation, 102, pp. 42-47, (2000)

[7]

Yudkin J.S., Stehouwer C.D., Emeis J.J., Coppack S.W., C-reactive protein in healthy subjects: association with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?, Arterioscler Thromb Vasc Biol, 19, pp. 972-978, (1999)

[8]

Ridker P.M., Buring J.E., Cook N.R., Rifai N., C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women, Circulation, 107, pp. 391-397, (2003)

[9]

Reaven G.M., Banting Lecture 1988. Role of insulin resistance in human disease, Diabetes, 37, pp. 1595-1607, (1998)

[10]

DeFronzo R.A., Ferrannini E., Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease, Diabetes Care, 14, pp. 173-194, (1991)

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