Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and Alzheimer patients

被引：118

作者：

Li, WP

Chan, WY

Lai, HWL

Yew, DT

机构：

[1] CHINESE UNIV HONG KONG,DEPT ANAT,SHATIN 100083,NT,HONG KONG

[2] FIRST MIL MED UNIV,DEPT NEUROL,GUANGZHOU,PEOPLES R CHINA

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 1997年 / 8卷 / 02期

关键词：

TUNEL-positive cells; differential regions; brain; normal aging; Alzheimer's disease;

D O I：

10.1007/BF02736774

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study investigated terminal dUTP nick-end labeling (TUNEL)-positive cells in the frontal, occipital, and hippocampal cortices of seven normal aging and four Alzheimer's patients. Significant increase in TUNEL-positive cells was observed in the frontal and hippocampal cortices of Alzheimer's patients when compared with controls. In the hippocampal cortex, only area CA4 demonstrated a significant increase of TUNEL-positive cells. Double staining of TUNEL-positive cells for glial fibrillary acidic protein revealed that <13% of the TUNEL-positive nuclei belonged to astrocytes. The results of this study illustrated a differential pattern of cortical degeneration between normal aging and Alzheimer patients.

引用

页码：75 / 82

页数：8

共 18 条

[1] DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay [J].