Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP

被引：23

作者：

Cherasse, Yoan ^{[1
]}

Chaveroux, Cedric ^{[1
]}

Jousse, Celine ^{[1
]}

Maurin, Anne-Catherine ^{[1
]}

Carraro, Valerie ^{[1
]}

Parry, Laurent ^{[1
]}

Fafournoux, Pierre ^{[1
]}

Bruhat, Alain ^{[1
]}

机构：

[1] INRA, UMR Human Nutr 1019, F-63122 St Genes Champanelle, France

来源：

FEBS LETTERS | 2008年 / 582卷 / 10期

关键词：

JDP2; amino acid response element; ATF2; CHOP;

D O I：

10.1016/j.febslet.2008.03.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The transcriptional activation of CHOP (C/EBP-homologous protein) by amino acid deprivation involves ATF2 and ATF4 binding at the amino acid response element within the promoter. In this report, we investigate the role of JDP2 (Jun Dimerization Protein 2) in the amino acid control of CHOP transcription following amino acid starvation. Our results show that JDP2 binds to the CHOP AARE in unstimulated cells and that its binding decreases following amino acid starvation. We demonstrate that JDP2 acts as a repressor and suggest that it could be functionally associated with HDAC3 to inhibit CHOP transcription. (C) 2008 Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.

引用

页码：1537 / 1541

页数：5

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